| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aim of this study was to investigate the relationship between oxidative stress and age-related disturbance of iron metabolism. It was shown that the 2,3-Dimethoxy-1,4-naphtoquinone (DMNQ), a superoxide generator, and 4-hydroxy-2-nonenal (4-HNE), a lipid peroxidation product, increased ferrous ion and inhibited IRP1 (Iron regulatory protein 1) activity in mProx24 cell (mouse proximal tubular cell) and HEK293 cell (human embryonic kidney cells). In addition, SOD1 KO (animal model of oxidative stress) mice showed abnormalities of brain iron metabolism and exhibited impaired motivational behavior in three-chamber social interaction tests. These results suggest that age-related oxidative stress may induce disturbance of iron metabolism.
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