Elucidation of the selective cytotoxicity of tomuruline, a novel thiazole-containing polyketide, under nutrient-starvation conditions
| Project/Area Number |
15K16555
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kogakuin University |
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Principal Investigator |
Ohno Osamu 工学院大学, 先進工学部, 准教授 (20436992)
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| Research Collaborator |
SUENAGA Kiyotake
MATSUNO Kenji
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | トムルリン / 栄養飢餓 / 呼吸鎖 / シアノバクテリア / カルキピロン / リプログラミング / 小胞体ストレス / tomuruline / kalkipyrone / kynurenine / 解答系 / キヌレニン / 2-deoxy-D-glucose / ミトコンドリア / 電子伝達系 / 解糖系 |
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| Outline of Final Research Achievements |
The biological activity of the novel thiazole-containing polyketide tomuruline was elucidated to be the selective cytotoxicity toward cancer cells under glucose-restricted conditions. In addition, it was proved that tomuruline exerted cytotoxicity based on its selective inhibitory activity against the mitochondrial complex I activity. Next, we searched for compounds that showed the selective cytotoxicity toward cancer cells under nutrient-starvation conditions, and isolated kalkipyrone from marine cyanobacterium collected in Okinawa. Kalkipyrone was found to show the same biological activity with that of tomuruline. Meanwhile, we isolated new inhibitors of kynurenine-production and ER stress using the screening systems related to the nutrient starvation in cancers.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis2017
Author(s)
Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M.
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Journal Title
Chem. Eur. J.
Volume: 23
Issue: 35
Pages: 8500-8509
DOI
Related Report
Peer Reviewed
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[Journal Article] Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a t-butyl Group from an Okeania sp. Marine Cyanobacterium.2016
Author(s)
Hidetoshi Ogawa, Arihiro Iwasaki, Shinpei Sumimoto, Yuki Kanamori, Osamu Ohno, Masato Iwaztsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi Omura, and Kiyotake Suenaga
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Journal Title
Journal of Natural Products
Volume: 79
Issue: 7
Pages: 1862-1866
DOI
Related Report
Peer Reviewed
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[Presentation] Isolation of tomuruline, a novel thiazole containing polyketide with selective cytotoxicity under glucose-restricted conditions2015
Author(s)
Osamu Ohno, Kyouhei Same, Chihiro Kudo, Shinpei Sumimoto, Toshiaki Teruya, Etsu Tashiro, Siro Simizu, Masaya Imoto, Kiyotake Suenaga
Organizer
Pacifichem 2015 conference
Place of Presentation
Hilton Hawaiian Village (Hawaii, USA)
Year and Date
2015-12-18
Related Report
Int'l Joint Research
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