Development of novel molecular tool for controlling sleep/wake cycle and feeding behavior
| Project/Area Number |
15K16557
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SAITOH Tsuyoshi 筑波大学, 国際統合睡眠医科学研究機構, 助教 (80609933)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | オレキシン / 睡眠覚醒 / 光ケージド化合物 / 作動薬 / 睡眠 / 覚醒 / ケージド化合物 / 拮抗薬 / スイッチング化合物 / 合成化学 / 神経科学 / 脳・神経 / 有機化学 |
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| Outline of Final Research Achievements |
Purpose of this project is to develop novel molecular tool for controlling sleep/wake cycle and feeding behavior. Especially, we employed photo-caging technique to control the orexin agonist activity with light. Our main discoveries are the followings; 1) We discovered novel potent and selective orexin 2 receptor agonist YNT-185 and explored the target brain region of this molecule. 2) We designed and synthesized photo-caged orexin receptor agonist based on the structure-activity relationship study of orexin receptor agonist. 3) The caged molecule was investigated the photoresponcibility and electrophisiological responce.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
Author(s)
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 22
Pages: 5731-5736
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists2015
Author(s)
Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
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Journal Title
J. Med. Chem
Volume: 58
Issue: 20
Pages: 7931-7937
DOI
Related Report
Peer Reviewed
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[Presentation] Design and synthesis of orexin 1 receptor selective antagonists2017
Author(s)
Sayaka Ohrui, Naoshi Yamamoto, Masahiro Yata, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Masashi Yanagisawa, Hiroshi Nagase
Organizer
Tsukuba Global Science Week (TGSW) 2017
Related Report
Int'l Joint Research
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