Development of a novel gel-display drug screening technique
| Project/Area Number |
15K16558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Passioura Toby 東京大学, 大学院理学系研究科(理学部), 特任助教 (60750239)
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | Chemical Biology / Peptide / Antibiotic / chemical biology / peptide / antibiotic |
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| Outline of Final Research Achievements |
The goal of this work was to identify new antibiotics for the treatment of drug resistant bacterial infections. We identified 16 candidate inhibitors of bacterial antibiotic-resistance enzymes. Four of which are highly potent and exhibited activity against enzymes from multiple different drug-resistant strains of bacteria. These compounds may be used to develop drugs for the treatment of antibiotic resistant bacterial infections.
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Report
(3 results)
Research Products
(4 results)
