| Project/Area Number |
15K16559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ペプチド / 自己組織化 / ヒドロゲル / 細胞 / 三次元培養 / イメージング |
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| Outline of Final Research Achievements |
Self-assembling peptide u(FFiK)2 was designed as an amphiphilic peptide and synthesized. u(FFiK)2 assembled into nanofibers with a β-sheet structure and formed transparent hydrogels under physiological condition. HeLa and HEK293 cells were encapsulated in u(FFiK)2 hydrogels without cytotoxicity. Various cells, HeLa, HEK293, HepG2, MCF7 and HT-29 were successfully cultured on hydrogel sheets of u(FFiK)2. In addition, HeLa and HEK293 cells were cultured on hydrogel fibers of u(FFiK)2.
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