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Establishment of an animal model of timing production for speech and investigation of brain locations involved in the timing control

Research Project

Project/Area Number 15K16566
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionKumamoto University

Principal Investigator

Nishimura Masataka  熊本大学, 大学院生命科学研究部(医), 助教 (80613398)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsリズム / コミュニケーション / 双方向性 / 時間 / 精度 / タイミング / 意図 / 慢性実験 / 自由行動下 / 人工感覚 / 高周波選択的難聴 / 音声コミュニケーション
Outline of Final Research Achievements

Appropriate timing and enough precision of speech production is essential for our vocal communication to represent our intention. In the present research, we aimed to establish an animal model which produces appropriate timing with enough precision to investigate the brain mechanism of timing production for quick actions such as speech, by using a conventional laboratory animal, guinea pig. We succeeded to condition guinea pigs to discriminate at most three timing cues and to switch timing of response for each cue. Guinea pigs produced timing with ±5% error (at minimum) for 0.3 sec timing, which is comparable to real vocal communication of guinea pig. Taken together, the animal model was successfully established and now we have a basis to study how brain produces timing to represent our intention with invasive techniques.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imaging2017

    • Author(s)
      Nishimura Masataka, Takemoto Makoto, Song Wen-Jie
    • Journal Title

      Brain Structure and Function

      Volume: 223(4) Issue: 4 Pages: 1599-1614

    • DOI

      10.1007/s00429-017-1574-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the somatosensory parietal ventral area and overlap of the somatosensory and auditory cortices in mice.2015

    • Author(s)
      Nishimura M, Sawatari H, Takemoto M, Song WJ.
    • Journal Title

      Neurosci Res.

      Volume: 99 Pages: 55-61

    • DOI

      10.1016/j.neures.2015.06.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Serveral-minute lasting extreme precision observed in a sub-second timing production task in guinea pigs2018

    • Author(s)
      Wang Chi, Yuta Shiromi, Wen-Jie Song, Masataka Nishimura
    • Organizer
      Neuroscience2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impacts of Millisecond-order Onset Timing Difference of High Frequency Component in Spectrally Complex Sounds on Cortrical Activity and Sensation2017

    • Author(s)
      Masataka Nishimura, Wen-Jie Song
    • Organizer
      ARO 2017 MidWinter Meeting
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Guinea pigs can learn to change behavioral response latency to report their sensation difference to three different sounds2016

    • Author(s)
      Chi Wang, Masataka Nishimura, Wen-Jie Song
    • Organizer
      The 3rd Annual Meeting of the Society for Bioacoustics
    • Place of Presentation
      Irago
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optical imaging-based parcellation of the marmoset auditory cortex2016

    • Author(s)
      Masataka Nishimura, Makoto Takemoto, Wen-Jie Song
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adaptive changes of cortical response to a monaural sound in a stream of binaural sounds2016

    • Author(s)
      Masataka Nishimura, Wen-Jie Song
    • Organizer
      新学術領域「適応回路シフト」国際シンポジウム
    • Place of Presentation
      同志社大学
    • Year and Date
      2016-03-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mating-Related Interactive Vocal Communication with Sub-centisecond Precision in Guinea Pigs2016

    • Author(s)
      Masataka Nishimura, Yuta Shiromi, Wen-Jie Song
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      San Diego
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A binaural compensatory mechanism in the auditory system: enhanced cortical response to a sound to the ipsilateral ear in a stream of binaural sounds2015

    • Author(s)
      Masataka Nishimura, Wen-Jie Song
    • Organizer
      The Society for Bioacoustics
    • Place of Presentation
      九州大学
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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