Optical imaging analysis of prediction error detection function in the posterior parietal cortex of mice.
Project/Area Number |
15K16572
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Brain biometrics
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 頭頂連合野 / 感覚連合 / 光学的機能イメージング / 細胞接着因子 / 予測誤差 / 視覚 / 体性感覚 / マウス / プロトカドヘリン / フラビン蛋白蛍光イメージング / 高次脳機能 / 後部頭頂連合野 |
Outline of Final Research Achievements |
We discovered that the posterior parietal cortex (PPC) of the visual system dorsal pathway responsible for spatial information processing responds to spatial discrepancies between visual information and whisker information. It was also found that it is necessary to normal experience both visual and whisker inputs in order to respond to this discrepancy in spatial information. This function was dependent on clustered protocadherin alpha, neuro-specific cell adhesion molecules. It was suggested that neural circuits dependent on molecular diversity of protocadherin are necessary for sensory integration.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] mpaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice.2015
Author(s)
Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukawa T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K
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Journal Title
J Neurochem
Volume: 133
Issue: 1
Pages: 66-72
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Functional footprints of impaired consciousness in mice with reduced molecular diversity of clustered protocadherin-α2016
Author(s)
Katsuei Shibuki, Tatsuya Yamagishi, Daiki Kamatani, Kohei Yoshitake, Hiroaki Tsukano, Kenji Watanabe, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Arata Horii, Takeshi Yagi
Organizer
Society for Neuroscience, Annual Meeting 2016
Place of Presentation
San Diego Convention Center, USA, San Diego
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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