| Project/Area Number |
15K17473
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Optical engineering, Photon science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
PAVILLON Nicolas 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (80644525)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | Optical measurement / Raman / Coherent imaging / 3D imaging / Label-free / Tissue imaging |
|---|
| Outline of Final Research Achievements |
We developed a system enabling the measurement of both structural and molecular information on tissue purely based on label-free technologies. The structural information is retrieved through optical coherence tomography, developed here in a full-field configuration, which enables parallel detection without requiring scanning. This system employs a wide-band excitation source based on a white-light supercontinuum that provides over 100 nm of bandwidth to reach isotropic micrometer resolution.
The molecular modality is based on a standard point-measurement Raman scanning system with a near-infrared excitation. While this approach typically requires long exposure times, it is here possible to employ the information retrieved from full-field OCT to specifically target regions of interest to rapidly retrieve the molecular information.
The system was characterized with phantoms containing plastic beads and ex vivo tissue.
|
