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Physical modeling of biological neural network and investigation of its dynamics

Research Project

Project/Area Number 15K17721
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Mathematical physics/Fundamental condensed matter physics
Research InstitutionChuo University

Principal Investigator

Okano Taiji  中央大学, 理工学部, 助教 (60622082)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsBelousov-Zhabotinsky反応 / エマルション / サイズ依存性 / 化学振動子 / リポソーム
Outline of Final Research Achievements

We investigated the size dependency of the Belousov-Zhabotinsky (BZ) reaction using water in oil (W/O) emulsion droplets. The BZ reaction encapsulated in emulsion droplet was significantly influenced by the droplet volume. For example, the minimum volume at which the reaction occurred was decreased with increasing the concentration of malonic acid. Furthermore, we found that the period of oscillation also depended on the reaction volume. Next, we investigated the stability of lipid vesicles (liposomes) in the BZ reaction mixture, which is a low pH solution. We found that liposomes composed of DMPC and DSPE-PEG 2000 were stable at pH 1 - 2, whereas liposomes composed of only DMPC were broken after replacing the outer solution with acidic solution.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Miniaturization of chemical oscillator and its size dependency2016

    • Author(s)
      Junya Wada, Hiroaki Suzuki, and Taiji Okano
    • Organizer
      International Symposium on Micro-Nano Science and Technology 2016
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学振動子の微小化と反応のサイズ依存性2015

    • Author(s)
      和田隼弥,鈴木宏明,岡野太治
    • Organizer
      化学とマイクロ・ナノシステム学会 第32回研究会
    • Place of Presentation
      北九州国際会議場(福岡県)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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