| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Dictyostelium Discoideum have polarities in their cell-cell adhesion and movement. These polarities function in inducing the variety of their collective migration. The present work focused on the polarity effect through cell-cell adhesion on the collective cell migration, the function of which have never recognized. In this work, I constructed the physical model of polarity in the cell-cell adhesion and on the basis of this model, we found the following foundings.
1) The polarity of cell-cell adhesion can conduct the movement of surrounding cell in the direction of polarity. 2) The polarity of cell-cell adhesion explains the arrangement of Dictyostelium Discoideum cells in their collective cell migration. 3) The persistence time control induces the dynamical transition between the collective movement and the individual movement.
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