| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
I have newly designed a series of fused oligomers of macrocycles with dynamic figure eight chirality. Dynamic features in solution of these fused oligomers were investigated through NMR, UV and CD spectroscopy.
For fused oligomers, the barrier to dynamic interconversion between two helical conformations with M- or P-helicity followed a specific pattern similar to that of the original unit of a macrocycle. Complexation and chiroptical properties were dependent on the molecular shape, that is a manner of fusion. We found a new perspective on "chiral amplification". In a fused trimer or a tetramer, the helical-sense preference increased with the number of units. These finding was brought about by quantitative observation of the helical-sense preferences through NMR spectroscopy in solution.
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