Construction of artificial cell encapsulating cross-catalyst system
| Project/Area Number |
15K17850
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
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Principal Investigator |
KURIHARA Kensuke 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特任准教授 (80740919)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ベシクル / 両親媒性分子 |
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| Outline of Final Research Achievements |
In Sugawara's self-reproducing vesicular systems, the vesicle containing amplified DNA self-reproduced more rapidly. It means that compartment and information interacted each other. However, little research has been done on the protocellular system in which reproduction of container interacts with reproduction of another element, i.e. catalyst. In order to realize the protocell containing the catalyst-producing system, we introduce a cross-catalytic vesicular system. In our protocell cell, production of the vesicular membrane molecules is accelerated by the catalyst synthesized in the same vesicle, whereas the catalysts are produced in the hydrophobic environment of the vesicular membrane. After addition of the membrane precursor to the vesicle containing synthesized catalyst, we observed self-reproduction of the vesicle. Furthermore, we succeeded in construction of the cellular system in which membrane molecules and catalysts coordinated by synthesizing from the same substances.
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Report
(3 results)
Research Products
(19 results)
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[Presentation] 化学で創る人工細胞2016
Author(s)
栗原顕輔
Organizer
細胞を創る研究会9.0
Place of Presentation
東京, 新宿区, 早稲田大学
Year and Date
2016-11-21
Related Report
Invited
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