| Project/Area Number |
15K17851
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Akagawa Kengo 東京大学, 生産技術研究所, 助教 (60548733)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | ペプチド触媒 / ライブラリスクリーニング / コンビナトリアル化学 / 不斉マイケル付加 |
|---|
| Outline of Final Research Achievements |
A facile screening method for finding active catalysts from the peptide library constructed in a combinatorial manner has been established. With this method, novel bifunctional peptide catalysts having N-terminal proline and a histidyl residue ware developed. The screening in aqueous media afforded the prolyl peptide with a lysine residue. In the presence of these peptide catalysts, asymmetric Michael addition could be performed with high efficiency and enantioselectivity. Notably, two kinds of histidine-containing peptides showed opposite enantioselectivities, although both peptides had common N-terminal residues. By applying the screening method to the reaction that could not be performed with other catalysts, the peptide effective for that reaction was successfully identified.
|
