| Project/Area Number |
15K17852
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Fuse Shinichiro 東京工業大学, 科学技術創成研究院, 准教授 (00505844)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 環状ペプチド / マイクロフロー合成 / 光反応 / NCA / マイクロフロー / 瞬間混合 / ペプチド / アミド化 |
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| Outline of Final Research Achievements |
Aim of this research was development of peptide chain elongation using alpha-amino acid-N-carboxy anhydride and photochemical cyclization of peptides for efficient cyclic peptide synthesis. We successfully developend and reported photochemical cyclization of peptides in an academic journal. On the other hand, peptide chain elongation using alpha-aminoacid-N-carboxy anhydride was rather difficult. In the couse of our research, however, we developed new synthetic approach for alpha-aminoacid-N-carboxy anhydrides. It alllowed us to synthesize alpha-aminoacid-N-carboxy anhydride that could not be synthesized by previously reported synthetic approaches.
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