Development of Phosphine-Borane Ligand for Unactivated Carbon-Oxygen Bond Cleavage
| Project/Area Number |
15K17858
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ONODERA Gen 長崎大学, 工学研究科, 准教授 (90433698)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ホスフィン－ボラン / パラジウム / アリルアルコール / アミノ化反応 / アルキル化反応 / ベンジルアルコール / アリル位アミノ化 / アリル位アルキル化 |
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| Outline of Final Research Achievements |
The aim of this study was developing the transition-metal-catalyst system to activate the C-O bond by using phosphine-borane ligand bearing Lewis acidic borane moiety. The various kinds of phosphine-borane compounds were prepared. Among these phosphine-borane compounds, the best ligand for the palladium-catalyzed direct allylic amination of allylic alcohol was found. As an application, the efficient palladium/phosphine-borane catalyst system for the allylic alkylation of allylic alcohol with active methylene compound was developed.
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Report
(3 results)
Research Products
(5 results)
