| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
We focused on glycopolymers which had pendant saccharides on a synthetic polymer backbone. Glycopolymers were designed and synthesized with the idea based on a protein structure. Acrylamide derivative glycomonomers were synthesized from free saccharides via 2 steps, direct anomeric azidation and copper-catalyzed azide-alkyne cycloaddition. The resulting glycomonomers were subjected to RAFT copolymerization with acrylamide and other monomer substrates. The glycopolymers were able to be suspended into water depend on the ratio of monomer units and formed core-shell aggregation. On binding assay of the glycopolymers with lectins, high binding affinity were observed.
|
