Design of Glycopolymers for Creating Glycoprotein Mimics
| Project/Area Number |
15K17870
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糖鎖高分子 / オリゴ糖 / RAFT重合 / 糖クラスター効果 / レクチン / コアシェル構造 / 温度応答性 / 保護基フリー / クリックケミストリー / 糖モノマー / 重合 |
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| Outline of Final Research Achievements |
We focused on glycopolymers which had pendant saccharides on a synthetic polymer backbone. Glycopolymers were designed and synthesized with the idea based on a protein structure. Acrylamide derivative glycomonomers were synthesized from free saccharides via 2 steps, direct anomeric azidation and copper-catalyzed azide-alkyne cycloaddition. The resulting glycomonomers were subjected to RAFT copolymerization with acrylamide and other monomer substrates. The glycopolymers were able to be suspended into water depend on the ratio of monomer units and formed core-shell aggregation. On binding assay of the glycopolymers with lectins, high binding affinity were observed.
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Report
(3 results)
Research Products
(22 results)
