Research Project
Grant-in-Aid for Young Scientists (B)
The highlights of this study are: (i) the chemical library screening allowed us to discover a highly-selective RNA G-quadruplex stabilizer with a new chemical scaffold and physical property, (ii) the protein expression level of endogenous NRAS, a well-known proto-oncogene, was down-regulated with the stabilizer in living cells for the first time, and (iii) the RNA G-quadruplex stabilizer enabled the detection of a previously unidentified RNA G-quadruplex in 5’-UTR of NRAS.
All 2017 2016 2015
All Journal Article (3 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 2 results, Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)
Angew. Chem. Int. Ed.
Volume: 56 Issue: 7 Pages: 1765-1770
10.1002/anie.201610284
J. Am. Chem. Soc.
Volume: 138 Issue: 29 Pages: 9037-9040
10.1021/jacs.6b04506
ファルマシア
Volume: 51 Pages: 459-459
130007448193