Functional Vaccine Carriers by using Chemically Modified Fullerene Nanostructures
| Project/Area Number |
15K17890
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
MINAMI KOSUKE 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMSポスドク研究員 (10747463)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ドラッグデリバリーシステム / フラーレン / ナノバイオ / 自己組織化 / 階層的自己組織化 / 生体組織工学 |
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| Outline of Final Research Achievements |
Vaccine has an emerging field for preventing serious diseases as well as for preventing and curing cancers. However, conventional vaccines have limitations for further applications. It is required that the carrier vehicles for effectively delivery of vaccines. We focused on the chemically functionalized fullerene nanostructures because of their properties as anti-oxidant and carrier for DDS. We synthesized the molecular libraries of chemically functionalized fullerene derivatives and precisely tuned their nanostructures. We used the liquid-liquid interfacial precipitation method for controlling fullerene nanostrucutes. We revealed that some of the fullerene library have applied for cellular scaffolds and showed no cytotoxicity. We are further investigating their properties to apply for vaccine carrier vehicles.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] In situ 2D-extraction of DNA wheels by 3D through-solution transport2015
Author(s)
Yusuke Yonamine *ab, Keitel Cervantes-Salguero *c, Waka Nakanishi *a, Ibuki Kawamata c, Kosuke Minami a, Hirokazu Komatsu a, Satoshi Murata *c, Jonathan P. Hill ab and Katsuhiko Ariga *ab
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Journal Title
Phys. Chem. Chem. Phys.
Volume: 17
Issue: 48
Pages: 32122-32125
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Vortex-Aligned Fullerene Nanowhiskers as a Scaffold for Orienting Cell Growth2015
Author(s)
Venkata Krishnan, Yuki Kasuya, Qingmin Ji, Marappan Sathish, Lok Kumar Shrestha, Shinsuke Ishihara, Kosuke Minami, Hiromi Morita, Tomohiko Yamazaki, Nobutaka Hanagata, Kun’ichi Miyazawa, Somobrata Acharya, Waka Nakanishi, Jonathan P. Hill, and Katsuhiko Ariga
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Journal Title
ACS Applied Materials & Interfaces
Volume: 7
Issue: 28
Pages: 15667-15673
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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