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Development of stochastic nonlinear finite-element method for simulating biomaterial with uncertainty

Research Project

Project/Area Number 15K17932
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Materials/Mechanics of materials
Research InstitutionThe University of Tokyo

Principal Investigator

Hatano Asuka  東京大学, 大学院工学系研究科(工学部), 講師 (20707202)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords流体構造連成解析 / 流体構造連成 / 医用画像 / 確率有限要素法 / 血管 / 狭窄 / 造影剤 / 有限要素法 / 不確定性 / 機械学習
Outline of Final Research Achievements

We developed Fluid-structure interaction finite element method for simulating flexible tube system with stenosis. The simulation results well reproduced experimental fluid velocity measurement literature data and our bifurcated phantom experiment data. Experiment and simulation showed good agreement with a temporal change of flow rate, pressure, and radius under 1 Hz square pulsatile flow.
Then we simulated convection of particle tracers generated at the inlet, imitating a gradual increase in contrast agent with 80% and 95% stenosis. With 80% stenosis, axially symmetric flow resulted in reproductive tracer distributions; however, with 95% stenosis, the direction of jet flow from the stenosis and subsequent helical flow varied every beat. We further developed and verified the stochastic nonlinear finite element method for fluid-structure interaction problem. An uncertain variable was set to the viscosity coefficient.

Academic Significance and Societal Importance of the Research Achievements

構造のシミュレーションは複雑な形状がシミュレーションできればよいという確定的シミュレーションの時代を経て,材料・加工・保守などの不確定要素に由来する確率的応答を考慮に入れた信頼性工学が発展し,実際の設計に不可欠なツールとして発展してきている.生体のシミュレーションに関しても,確定的なシミュレーションを行う技術は確立してきており、生体シミュレーションにも「品質」が求められるようになってきている.本研究による生体シミュレーションの不確かさを定量化する手法の確立は,診断支援など医学的応用を考える上で必要不可欠であり生体シミュレーションが実際に社会に役立つために不可欠な基礎技術である.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2016 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Phantom experiment and ALE fluid structure interaction analysis of contrast agent dynamics through an elastic stenosis after bifurcation2018

    • Author(s)
      HATANO Asuka、SUMIYOSHITANI Jun、SUZUKI Kazuma、GORYU Akihiro、KANO Akira、KATO Mitsuaki、HIROHATA Kenji、IZUMI Satoshi
    • Journal Title

      Transactions of the JSME (in Japanese)

      Volume: 84 Issue: 863 Pages: 18-00015-18-00015

    • DOI

      10.1299/transjsme.18-00015

    • NAID

      130007418706

    • ISSN
      2187-9761
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 狭窄柔軟管内流れの解析における境界条件と物性値の影響度評価2018

    • Author(s)
      鈴木一真、波田野明日可、高本聡、泉聡志
    • Organizer
      生体医工学シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 狭窄を伴う柔軟管内拍動流の流体構造連成解析2016

    • Author(s)
      住吉谷淳,波田野明日可,牛流章弘,加納明,加藤光章,廣畑賢治,泉聡志,酒井信介
    • Organizer
      日本機械学会 第27回バイオフロンティア講演会
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Remarks] 狭窄管内流れのFSI有限要素解析と造影剤動態解明

    • URL

      http://www.fml.t.u-tokyo.ac.jp/research.html#09

    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2020-03-30  

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