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Determination of optical properties for biological tissue based on radiative transport model in fine structure of biological tissue

Research Project

Project/Area Number 15K17980
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Thermal engineering
Research InstitutionHokkaido University

Principal Investigator

Fujii Hiroyuki  北海道大学, 工学研究院, 助教 (00632580)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生体内光伝搬 / ふく射輸送方程式 / 光学特性値 / 生体光イメージング / 微細構造
Outline of Final Research Achievements

The objectives of this study were to examine light propagation in biological tissue with fine structure using the radiative transfer equation, and to determine the optical properties of the tissues using an inverse algorithm.
Firstly, an accurate and efficient numerical scheme was developed for solving the radiative transfer equation in highly forward-directed scattering media such as biological tissue.From the numerical results of the RTE, the transition length and time from ballistic light to diffusive light were evaluated as a function of the optical properties. Secondly,the time-resolved profiles of light in agricultural and food products were measured and the in-vivo and ex-vivo optical properties of them were evaluated using the inverse analysis. It was suggested the optical properties were related with the structural properties.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results) Remarks (8 results) Funded Workshop (1 results)

  • [Journal Article] Light propagation model of titanium dioxide suspensions in water using the radiative transfer equation.2017

    • Author(s)
      Fujii H, Yamada Y, Hoshi Y, Okawa S, Kobayashi K, Watanabe M.
    • Journal Title

      React Kinet Mech Cat

      Volume: 123 Issue: 2 Pages: 439-453

    • DOI

      10.1007/s11144-017-1328-2

    • NAID

      120006600941

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling of light propagation in the human neck for diagnoses of thyroid cancers by diffuse optical tomography2017

    • Author(s)
      Fujii Hiroyuki、Yamada Yukio、Kobayashi Kazumichi、Watanabe Masao、Hoshi Yoko
    • Journal Title

      International Journal for Numerical Methods in Biomedical Engineering

      Volume: 33 Issue: 5 Pages: 591-604

    • DOI

      10.1002/cnm.2826

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renormalization of the highly forward-peaked phase function using the double exponential formula for radiative transfer2016

    • Author(s)
      Fujii, H., Okawa, S., Yamada, Y., Hoshi, Y., Watanabe, M.
    • Journal Title

      Journal of Mathematical Chemistry

      Volume: 54 Issue: 10 Pages: 2048-2061

    • DOI

      10.1007/s10910-016-0670-3

    • NAID

      120006360048

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Numerical study of photon migration in the presence of a void region using the radiative transfer and diffusion equations2016

    • Author(s)
      Erina Miyakawa, Hiroyuki Fujii, Kiyohito Hattori, Yuki Tatekura, Kazumichi Kobayashi and Masao Watanabe
    • Journal Title

      AIP Conference Proceedings (ICCMSE2016)

      Volume: 1790 Pages: 0500031-4

    • DOI

      10.1063/1.4968672

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Normalization method of highly forward-peaked scattering phase function using the double exponential formula for radiative transfer2016

    • Author(s)
      Hiroyuki Fujii, Shinpei Okawa, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Journal Title

      AIP Conference Proceedings (ICCMSE2016)

      Volume: 1790 Pages: 0500021-4

    • DOI

      10.1063/1.4968671

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Numerical Modeling of Photon Migration in Human Neck Based on the Radiative Transport Equation2016

    • Author(s)
      Hiroyuki Fujii, Shinpei Okawa, Ken Nadamoto, Eiji Okada, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Journal Title

      Journal of Applied Nonlinear Dynamics

      Volume: 5 Issue: 1 Pages: 117-125

    • DOI

      10.5890/jand.2016.03.009

    • NAID

      120005725146

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 拡散光トモグラフィ-:現状と展望2016

    • Author(s)
      星 詳子,藤井 宏之,橋本 康
    • Journal Title

      レーザー研究

      Volume: 44 Pages: 230-234

    • NAID

      130007957202

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Numerical study of light propagation in agricultural products for non-destructive assessment of food quality2015

    • Author(s)
      Kiyohito Hattori, Hiroyuki Fujii, Yuki Tatekura, Kazumichi Kobayashi, and Masao Watanabe
    • Journal Title

      Proceedings of SPIE for Biophotonics Japan 2015

      Volume: 9792 Pages: 1-5

    • DOI

      10.1117/12.2204799

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A coupling model of the radiative transport equation for calculating photon migration in biological tissue2015

    • Author(s)
      Fujii Hiroyuki, Shinpei Okawa, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Journal Title

      Proceedings of SPIE for Biophotonics Japan 2015

      Volume: 9792 Pages: 1-5

    • DOI

      10.1117/12.2203638

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 拡散光による甲状腺腫瘍診断のためのヒト頸部内 における光伝播の数値解析2017

    • Author(s)
      藤井宏之,山田幸生,星 詳子,小林一道,渡部正夫
    • Organizer
      第33回近赤外フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Numerical Calculation of Time-Resolved Light Reflectance from Biological Tissue Using the Radiative Transfer Equation2017

    • Author(s)
      Fujii Hiroyuki、Yamada Yukio、Hoshi Yoko、Okawa Shinpei、Kobayashi Kazumichi、Watanabe Masao
    • Organizer
      Mathematics in (bio)Chemical Kinetics and Engineering (MaCKiE) 2017 conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical investigation of light and pressure propagation in biological tissue for model-based photoacoustic tomography2017

    • Author(s)
      Tabayashi Kosuke、Fujii Hiroyuki、Kobayashi Kazumichi、Watanabe Masao
    • Organizer
      Ninth JSME-KSME Thermal and Fluids Engineering Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical solver of the 3D radiative transfer equation in turbid media with anisotropic scattering based on the discrete ordinates method2017

    • Author(s)
      Hiroyuki Fujii
    • Organizer
      Inverse problems and medical imaging
    • Place of Presentation
      The University of Tokyo, Tokyo
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Normalization method of highly forward-peaked scattering phase function using the double exponential formula for radiative transfer2016

    • Author(s)
      Hiroyuki Fujii, Shinpei Okawa, Ken Nadamoto, Eiji Okada, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Organizer
      ICCMSE 2016
    • Place of Presentation
      メトロポリタンホテル(アテネ・ギリシャ)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical study of photon migration in the presence of a void region using the radiative transfer and diffusion equations2016

    • Author(s)
      Erina Miyakawa, Hiroyuki Fujii, Kiyohito Hattori, Yuki Tatekura, Kazumichi Kobayashi and Masao Watanabe
    • Organizer
      ICCMSE 2016
    • Place of Presentation
      メトロポリタンホテル(アテネ・ギリシャ)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative Method to Determine the Optical Properties of Melons by the Photon Diffusion Equation2016

    • Author(s)
      Kiyohito Hattori, Hiroyuki Fujii, Goro Nishimura, Kazumichi Kobayashi and Masao Watanabe
    • Organizer
      The 5th Asian NIR Symposium
    • Place of Presentation
      Hotel Shiroyama, Kagoshima
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optical properties of melons determined by an analysis based on the photon diffusion equation2016

    • Author(s)
      Kiyohito Hattori, Hiroyuki Fujii, Goro Nishimura, Kazumichi Kobayashi and Masao Watanabe
    • Organizer
      1st Food Chemistry Conference
    • Place of Presentation
      NH Grand Hotel Krasnapolsky, Amsterdam
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical study of light propagation in agricultural products for non-destructive assessment of food quality2015

    • Author(s)
      Kiyohito Hattori, Hiroyuki Fujii, Yuki Tatekura, Kazumichi Kobayashi, and Masao Watanabe
    • Organizer
      Biophotonics Japan 2015
    • Place of Presentation
      筑波大学東京キャンパス(東京都文京区)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A coupling model of the radiative transport equation for calculating photon migration in biological tissue2015

    • Author(s)
      Fujii Hiroyuki, Shinpei Okawa, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Organizer
      Biophotonics Japan 2015
    • Place of Presentation
      筑波大学東京キャンパス(東京都文京区)
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical analysis of photon migration in three-dimensional turbid media using the delta-Eddington approximation2015

    • Author(s)
      Hiroyuki Fujii, Shinpei Okawa, Ken Nadamoto, Eiji Okada, Yukio Yamada, Yoko Hoshi, and Masao Watanabe
    • Organizer
      the 9th ICME International Conference on Complex Medical Engineering (CME 2015)
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] Research map

    • URL

      https://researchmap.jp/fujii-hr/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 北海道大学大学院工学研究院熱流体物理学研究室HP

    • URL

      http://labs.eng.hokudai.ac.jp/labo/fluid/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 北海道大学学術成果コレクション(HUSCAP)

    • URL

      https://eprints.lib.hokudai.ac.jp/statistics/statslist.php?statsurl=0gf3a06zpv7h93c

    • Related Report
      2017 Annual Research Report
  • [Remarks] research map

    • URL

      http://researchmap.jp/fujii-hr/

    • Related Report
      2016 Research-status Report
  • [Remarks] えんじにあRing

    • URL

      http://www.eng.hokudai.ac.jp/engineering/2016-01/feature1601-03.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 所属研究室 HP

    • URL

      http://labs.eng.hokudai.ac.jp/labo/fluid/

    • Related Report
      2016 Research-status Report
  • [Remarks] researchmap

    • URL

      http://researchmap.jp/fujii-hr/

    • Related Report
      2015 Research-status Report
  • [Remarks] 研究室HP

    • URL

      http://labs.eng.hokudai.ac.jp/labo/fluid/

    • Related Report
      2015 Research-status Report
  • [Funded Workshop] INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 20162016

    • Place of Presentation
      メトロポリタンホテル(アテネ・ギリシャ)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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