Microvoid cell manipulation and its application into porus-tissue engineering
| Project/Area Number |
15K18004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Tanaka Nobuyuki 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (00724692)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞操作 / 物理化学 / 表面張力 / 細胞培養 / 組織工学 / 幹細胞 / 大腸菌 / 気泡 / 多孔質立体組織 / 自発的作用 |
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| Outline of Final Research Achievements |
In this research, we aimed to realize a high throughput cell manipulation method utilizing physico-chemical properties. During the research period, we developed a cell patterning technique using bubbles and interfacial properties, especially using surface tension as a key word.
When many bubbles with uniform size are generated in liquid, they can spontaneously be aligned in a hexagonal shape. By further pouring the liquid containing the cells into the aligned bubbles, the surface of the aligned bubbles became a kind of wall for cells, resulting in that hexagonal-patterned cell culture system was realized. As another candidate of "cell wall", we suggested that agar was quite useful material. In addition, by increasing the number of cells, we also performed the fabrication of thicker cellular tissue.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Correlative near-infrared light and cathodoluminescence microscopy using Y2O3:Ln, Yb (Ln = Tm, Er) nanophosphors for multi-scale, multi-colour bioimaging2016
Author(s)
Fukushima, S., Furukawa, T., Niioka, H., Ichimiya, M., Sannomiya, T., Tanaka, N., Onoshima, D., Yukawa, H., Baba, Y., Miyake, J., Ashida, M., Araki, T., and Hashimoto, M.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 25950-25950
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Correlative near-infrared light and cathodoluminescence microscopy using Y2O3:Ln, Yb (Ln = Tm, Er) nanophosphors for multi-scale, multi-colour bioimaging2016
Author(s)
1.S. Fukushima, T. Furukawa, H. Niioka, M. Ichimiya, T. Sannomiya, N. Tanaka, D. Onoshima, H. Yukawa, Y. Baba, M. Ashida, J. Miyake, T. Araki, and M. Hashimoto
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Journal Title
Scientific Reports
Volume: -
Related Report
Peer Reviewed / Open Access
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