Development of highly sensitive near-field terahertz sensors for the measurement of trace amount of solutions

• Project/Area Number: 15K18053
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Electron device/Electronic equipment
• Research Institution: Osaka University
• Principal Investigator: Serita Kazunori 大阪大学, レーザー科学研究所, 特任助教 (00748014)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: テラヘルツ / 非線形光学 / マイクロ流路 / メタマテリアル / バイオセンシング / テラヘルツ波 / 非線形光学結晶 / 局所場光物性 / イオン濃度 / 血糖値 / 血液 / 磁性ナノ中空粒子 / CoFe2O4 / ポーラロンモデル / 局所発生テラヘルツ / 円形微小開孔 / メタアトム

Outline of Final Research Achievements

We have proposed and developed a nonlinear optical crystal (NLOC)-based THz sensors for the ultra-trace measurements of solutions. The proposed sensors operate on the basis of near-field interaction between samples and a local emission of a point-like THz source that is generated in the process of optical rectification in the NLOC on a sub-wavelength scale. Using these sensors, we successfully detected femtomole order of solute in a less than 100 picolitter volume of the solutions. We also developed a reflection type THz near-field spectroscopic imaging system equipped with the THz sensors and succeeded in obtaining highly spatial resolution images of biological tissue samples.

Academic Significance and Societal Importance of the Research Achievements

生活習慣病などの初期診断を患者がほぼ無痛で行える波及効果の高い診断の提供が期待できる。また、タンパク質などの複雑な高次構造や機能性発現メカニズムに関する新規知見取得にもつながる可能性がある。非線形光学結晶も比較的安価でウエハ単位での入手が可能であることから衛生的な使い捨てタイプのチップとして利用可能である。本研究が、これまで困難であったバイオ・医療分野におけるTHzセンシング技術の産業応用発展と生体機能に関する新規知見取得に大いに貢献すると考えている。

Research Products

• [Int'l Joint Research] Vienna University of Technology(Austria)
• [Int'l Joint Research] ボーズ国立基礎科学研究センター(インド)
• [Journal Article] Terahertz microfluidic chips sensitivity-enhanced with a few arrays of meta-atoms (2018)
  • Author(s): K. Serita, E. Matsuda, K. Okada, I. Kawayama. H. Murakami, M. Tonouchi
  • Journal Title: APL Photonics Volume: 3 Issue: 5 Pages: 051603-051603
  • DOI: 10.1063/1.5007681
  • Peer Reviewed / Open Access
• [Journal Article] テラヘルツ波を用いた超高感度バイオケミカルセンサーチップの開発 ―次世代医療を強力にサポートするバイオセンシングの新技術― (2018)
  • Author(s): 芹田和則
  • Journal Title: レーザー研の広場 Volume: 16 Pages: 13-15
• [Journal Article] Direct Measurements of Terahertz Meta-atoms with Near-Field Emission of Terahertz Waves (2017)
  • Author(s): K. Serita, J. Darmo, I. Kawayama. H. Murakami, M. Tonouchi
  • Journal Title: Journal of Infrared, Millimeter, and Terahertz Waves Volume: 38 Issue: 9 Pages: 1107-1119
  • DOI: 10.1007/s10762-017-0417-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] バイオ応用に向けた反射型レーザー走査近接場テラヘルツ分光・イメージングシステムの開発 (2017)
  • Author(s): 岡田航介、芹田和則、村上博成、川山巌、斗内政吉
  • Journal Title: 信学技報 Volume: 117 Pages: 21-24
• [Journal Article] THz conductivity of semi-insulating and magnetic CoFe2O4 nanohollow structures through thermally activated polaron (2016)
  • Author(s): R. Rakshit, K. Serite, M. Tonouchi, K. Mandal
  • Journal Title: Journal of Applied Physics Volume: 120 Issue: 20 Pages: 203901-203901
  • DOI: 10.1063/1.4967923
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Magnetic resonance of terahertz metamaterials in parallel plate waveguide (2016)
  • Author(s): M. Razanoelina, K. Serita, E. Matsuda, I. Kawayama, H. Murakami, M. Tonouchi
  • Journal Title: Applied Physics Express Volume: 9 Issue: 3 Pages: 032002-032002
  • DOI: 10.7567/apex.9.032002
  • NAID: 210000137812
  • Peer Reviewed / Open Access
• [Journal Article] Acoustic vibration induced high electromagnetic responses of Fe3O4 nano-hollow spheres in THz regime (2015)
  • Author(s): R. Rakshit, D. Sarkar, M. Pal, K. Serite, M. Tonouchi, K. Mandal
  • Journal Title: Journal of Physics D: Applied Physics Volume: 48 Issue: 24 Pages: 245301-245301
  • DOI: 10.1088/0022-3727/48/24/245301
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characterization of Terahertz Imagers Using a Narrowband Time-Domain Terahertz Radiation and Detection System (2015)
  • Author(s): R. Sourav, K.Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Journal Title: IEICE Transactions on Electronics Volume: E98.C Issue: 12 Pages: 1128-1130
  • DOI: 10.1587/transele.E98.C.1128
  • NAID: 130005112306
  • ISSN: 0916-8524, 1745-1353
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Reflection type scanning laser terahertz near-field spectroscopy and imaging system for bio-applications (2018)
  • Author(s): K. Okada, K. Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: Conference on Lasers and Electro-Optics (CLEO2018)
  • Int'l Joint Research
• [Presentation] 非対称メタマテリアル構造を利用した高感度テラヘルツマイクロ流路チップの開発 (2018)
  • Author(s): 芹田和則、川山巌、村上博成、斗内政吉
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] PDMSマイクロ流路一体型テラヘルツチップによる微量溶液の測定 (2018)
  • Author(s): 田家稜平、濱田輝、芹田和則、北岸恵子、川井隆之、川山巌、村上博成、斗内政吉
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] 微量溶液分析に向けたテラヘルツバイオチップとその計測基盤技術の開発 (2018)
  • Author(s): 芹田和則
  • Organizer: レーザー学会「レーザーバイオ医療」技術専門委員会
  • Invited
• [Presentation] A terahertz microfluidic chip for ultra-trace measurement of solution (2018)
  • Author(s): K. Serita, E. Matsuda, K. Okada, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: The 9th International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW2018)
  • Int'l Joint Research / Invited
• [Presentation] 微量溶液測定用高感度テラヘルツマイクロ流路チップの開発 (2018)
  • Author(s): 芹田和則
  • Organizer: 「表面界面の機能創成とデバイス応用」セミナー
• [Presentation] キャピラリーを用いた分離分析へのテラヘルツ分光検出の試み (2017)
  • Author(s): 北岸恵子、濱田輝、芹田和則、斗内政吉、川井隆之
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2017-03-14
• [Presentation] A Small Aperture Terahertz Chip for Ultra-trace Blood Glucose Level Measurement (2017)
  • Author(s): K. Serita, K. Okada, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: Conference on Lasers and Electro-Optics (CLEO2017)
  • Int'l Joint Research
• [Presentation] Near-field Measurements of Terahertz Meta-atoms with Localized Terahertz Sources (2017)
  • Author(s): K. Serita, J. Darmo, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 78th Autumn Meeting, JSAP-OSA Joint Symposia 2017
  • Int'l Joint Research
• [Presentation] Evaluation of moisturizing effect of ceramides on skins using terahertz time-domain spectroscopy (2017)
  • Author(s): H. Kashiwada, H. Nakamura, K. Serita, K. Fukuda, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research
• [Presentation] Scanning laser terahertz near-field reflection spectroscopy and imaging system for bio-applications (2017)
  • Author(s): K. Okada, K. Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research
• [Presentation] Properties of a GaAs photoconductive switch with gold nanoparticles for THz detector using 1560 nm wavelength laser (2017)
  • Author(s): T. Takarada, K. Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research
• [Presentation] Application of terahertz near-field spectroscopic detection to micro-flow channels with high sensitivity for biological sample analyses (2017)
  • Author(s): K. Kitagishi, K. Serita, K. Hamada, T. Kawai, I. Kawayama, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research
• [Presentation] Development of scanning terahertz differential time-domain spectroscopy system for high sensitive measurements of trace amount of solutions (2017)
  • Author(s): K. Hamada, K. Serita, K. Kitagishi, T. Kawai, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research
• [Presentation] Terahertz Micro Total Analysis System (2017)
  • Author(s): K. Serita, E. Matsuda, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: THz Mansion Meeting
  • Int'l Joint Research
• [Presentation] テラヘルツ分光に適した新規マイクロ流路デバイス作製の試み (2017)
  • Author(s): 芹田和則、濱田輝、北岸恵子、川井隆之、斗内政吉
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] キャピラリーやμ-TASを用いたテラヘルツ分光のバイオ応用の試み (2017)
  • Author(s): 北岸恵子、芹田和則、濱田輝、川井隆之、斗内政吉
  • Organizer: 日本生物高分子学会
• [Presentation] マイクロ流路を用いた生体試料分析への近接場テラヘルツ分光検出法の応用の試み (2017)
  • Author(s): 北岸 恵子、芹田 和則, 濱田輝, 川井隆之, 川山 巌, 斗内 政吉
  • Organizer: キャピラリー電気泳動シンポジウム
• [Presentation] バイオ応用に向けた反射型レーザー走査近接場テラヘルツ分光・イメージングシステムの開発 (2017)
  • Author(s): 岡田 航介、芹田 和則、川山巌、村上博成、斗内政吉
  • Organizer: 電子情報通信学会 電子デバイス研究会
• [Presentation] 高空間分解能、高感度テラヘルツ分光のバイオ分野への応用の試み", 先端テラヘルツ研究とその応用展開 (2017)
  • Author(s): 北岸恵子、芹田和則
  • Organizer: 応用物理学会・テラヘルツ電磁波技術研究会
  • Invited
• [Presentation] Highly-sensitive terahertz microfluidic chip with a few arrays of symmetry broken resonators (2017)
  • Author(s): K. Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 8th International Symposium on Terahertz Nanoscience (TeraNano 8)
  • Int'l Joint Research / Invited
• [Presentation] A Terahertz Microfluidic Chip for Measurement of Trace Amount of Liquid (2016)
  • Author(s): K. Serita, E. Matsuda, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 20th SANKEN International Symosium
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-12-12
  • Int'l Joint Research
• [Presentation] Ultra-trace Measurement of Blood Glucose Level using Small Aperture Terahertz Chip (2016)
  • Author(s): K. Okada, K. Serita, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: The 20th SANKEN International Symosium
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2016-12-12
  • Int'l Joint Research
• [Presentation] 微小開口型テラヘルツチップによる血糖値の微量測定 (2016)
  • Author(s): 岡田航介、芹田和則、村上博成、川山巌、斗内政吉
  • Organizer: 第77回応用物理学会学術講演会
  • Place of Presentation: 朱鷺メッセ、新潟
  • Year and Date: 2016-09-13
• [Presentation] Development of THz-μTAS for measurement of Trace amount of liquid (2016)
  • Author(s): K. Serita, E. Matsuda, K. Okada, I. Kawayama, H. Murakami, M. Tonouchi
  • Organizer: Conference on Lasers and Electro-Optics (CLEO2016)
  • Place of Presentation: San Jose, CA, USA
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] 近接場テラヘルツ放射顕微鏡/分光による微量液体分析 (2016)
  • Author(s): 芹田和則、松田栄輝、岡田航介、村上博成、川山巌、斗内政吉
  • Organizer: 第 6 回高強度レーザー施設共用促進セミナー ～テラヘルツ波研究の最前線～
  • Place of Presentation: 大阪大学中之島センター
  • Year and Date: 2016-01-27
  • Invited
• [Presentation] 高密度テラヘルツ波励起メタマテリアルによる微量液体の測定 (2015)
  • Author(s): 松田栄輝、芹田和則、岡田航介、村上博成、川山巌、斗内政吉
  • Organizer: 電子情報通信学会 電子デバイス研究会
  • Place of Presentation: 東北大学
  • Year and Date: 2015-12-21
• [Presentation] テラヘルツ波集光メタマテリアルによる微量液体の評価 (2015)
  • Author(s): 松田栄輝、芹田和則、岡田航介、村上博成、川山巌、斗内政吉
  • Organizer: 第76回応用物理学会学術講演会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-09-13
• [Presentation] Development of scanning laser THz time-domain spectroscopy system (2015)
  • Author(s): K. Serita, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] Evaluation of trace amounts of liquid using THz metamaterials (2015)
  • Author(s): E. Matsuda, K. Okada, K. Serita, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] Trace analysis of glucose solutions using micro-hole in THz frequency region (2015)
  • Author(s): K. Okada, E. Matsuda, K. Serita, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] Synthesis and THz absorption performance of CoFe2O4 nano-hollow spheres (2015)
  • Author(s): K. Mandal, R. Rakshit, K. Serita, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] THz responses of Fe3O4 and SiO2@Fe3O4 nano-hollow spheres (2015)
  • Author(s): K. Mandal, R. Rakshit, K. Serita, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] Fundamental Research into Skin Moisture Retention Measurement Using Terahertz Electromagnetic Wave (2015)
  • Author(s): K. Fukuda, M. Kawamori, K.Serita, T. Umegaki, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: The 6th International Symposium on Terahertz Nanoscience (TeraNano 6)
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2015-07-01
  • Int'l Joint Research
• [Presentation] Evaluation of trace amounts of liquid using THz waves (2015)
  • Author(s): K. Serita, H. Murakami, I. Kawayama, M. Tonouchi
  • Organizer: Conference on Lasers and Electro-Optics (CLEO2015)
  • Place of Presentation: San Jose, CA, USA
  • Year and Date: 2015-05-10
  • Int'l Joint Research
• [Presentation] 局所テラヘルツ場による微量溶液分析の研究 (2015)
  • Author(s): 芹田和則
  • Organizer: 国際光年記念シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2015-04-21
• [Remarks] テラヘルツ波を用いた超高感度バイオケミカルセンサーチップの開発
  • URL: http://resou.osaka-u.ac.jp/ja/research/2018/20180214_1
• [Patent(Industrial Property Rights)] 測定用デバイス、及びそれを用いた測定装置 (2016)
  • Inventor(s): 芹田和則、斗内政吉、村上博成、川山巌、北岸恵子
  • Industrial Property Rights Holder: 芹田和則、斗内政吉、村上博成、川山巌、北岸恵子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-26
  • Overseas
• [Patent(Industrial Property Rights)] 測定用デバイス、及びそれを用いた測定装置 (2015)
  • Inventor(s): 芹田和則、斗内政吉、村上博成、川山巌、北岸恵子
  • Industrial Property Rights Holder: 芹田和則、斗内政吉、村上博成、川山巌、北岸恵子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-169826
  • Filing Date: 2015-08-28