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Design of microfluidic distributor with the ability to monitor blockage

Research Project

Project/Area Number 15K18264
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Reaction engineering/Process system
Research InstitutionKyoto University

Principal Investigator

Tonomura Osamu  京都大学, 工学研究科, 助教 (70402956)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsマイクロリアクタ / モニタリング / 閉塞検出 / 流体分配 / 設計 / センサ配置 / 最適化 / 閉塞検出・診断
Outline of Final Research Achievements

In order to realize mass production using microreactors, it is important to develop not only a method for realizing uniform flow distribution among the parallelized microreactors but also their monitoring method. The purpose of this study was design of microfluidic distribution devices with a function of detecting blocked microreactors. Given the number of reactors, the number of blockages, the fluid distribution structure, the throughput, and the number of sensors, the channel resistances and sensor locations in the microfluidic distribution device are optimized so as to achieve equal flow distribution under the normal condition and maximize the blockage detection performance under the abnormal condition. The effectiveness of the developed method and device is verified through both experiment and simulation.

Academic Significance and Societal Importance of the Research Achievements

マイクロ化学プロセスの最大の課題である閉塞を検出・診断できる機能を備えた装置並列化(ナンバリングアップ)による生産量増大いう考え方は他に類を見ない本研究の特色である。その実用に向けて流体分配構造・流路抵抗・センサ位置の最適化を図るアルゴリズムを開発した点は社会的に意義深く,また,計測や制御のし易さを評価に加えた装置設計に取り組んだ本研究は学術的にも極めて意義深い。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results)

  • [Journal Article] Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors2019

    • Author(s)
      Osamu Tonomura, Satoshi Taniguchi, Kazuki Nishi, Aiichiro Nagaki, Jun-ichi Yoshida, Katsuyuki Hirose, Norio Ishizuka and Shinji Hasebe
    • Journal Title

      Catalysts

      Volume: 9 Issue: 4 Pages: 308-319

    • DOI

      10.3390/catal9040308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsaltan2016

    • Author(s)
      Aiichiro Nagaki, Katsuyuki Hirose, Osamu Tonomura, Satoshi Taniguchi, Toshiki Taga, Shinji Hasebe, Norio Ishizuka, and Jun-ichi Yoshida
    • Journal Title

      Org. Process Res. Dev.

      Volume: 20 Issue: 3 Pages: 687-691

    • DOI

      10.1021/acs.oprd.5b00414

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Blockage detection and diagnosis in micro chemical plants with numbering-up structure2018

    • Author(s)
      Osamu Tonomura, Satoshi Taniguchi and Shinji Hasebe
    • Organizer
      15th International Conference on Microreaction Technology (IMRET)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Operation of Micro Chemical Processes: Recent Research Activities2018

    • Author(s)
      Osamu Tonomura
    • Organizer
      Ajinomoto Bio-Pharma Services(Wetteren, Belgium)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 閉塞診断機能を有する流体分配装置を用いた並列多段混合プロセスの設計2018

    • Author(s)
      殿村修・辻諒太郎・谷口智・長谷部伸治
    • Organizer
      化学工学会 第50回秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ化学合成・生産システム研究とその応用2018

    • Author(s)
      殿村修
    • Organizer
      スマートコンビナート研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 触媒担持モノリス充填カラムを用いた並列反応システムの開発:閉塞診断機能を有する流体分配器の最適設計2017

    • Author(s)
      殿村修,西和希,谷口智,永木愛一郎,廣瀬勝幸,長谷部伸治,石塚紀生,吉田潤一
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県・横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] マイクロ化学プロセスにおける気液スラグ流生成システムの設計と操作2017

    • Author(s)
      殿村修,尾鍋洋次郎,宮林圭輔,谷口智,長谷部 伸治
    • Organizer
      化学工学会 第82年会
    • Place of Presentation
      芝浦工業大学 豊洲キャンパス(東京都・江東区)
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of Predictive Model for Sizes of Gas and Liquid Slugs Formed in Millimeter-Scale T-Shaped Channels2017

    • Author(s)
      Gwangnoh Ahn, Osamu Tonomura, Satoshi Taniguchi, Aoyama Tomoya and Shinji Hasebe
    • Organizer
      AIChE Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロ化学プラントの設計・運転・制御2017

    • Author(s)
      殿村修
    • Organizer
      化学工学会関西支部マイクロプロセス最前線シリーズ
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 並列マイクロリアクタの複数閉塞診断のための流体分配器とセンサ位置の最適化2017

    • Author(s)
      谷口智,畑慶,殿村修,長谷部伸治
    • Organizer
      化学工学会第49回秋季大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Monitoring of Two-phase Slug Flow in T-shaped Micro-channels by Feed Pressure Measurements2017

    • Author(s)
      Osamu Tonomura, Keisuke Miyabayashi, Ryuichi Kobori, Satoshi Taniguchi, Shinji Hasebe
    • Organizer
      the joint AMN/ISMM/APBCM/ANZNMF meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 充填層型コンパクトリアクタ内の気液流動様式推定2016

    • Author(s)
      殿村修 ,荒居直道,谷口智,長谷部伸治
    • Organizer
      日本プロセス化学会2016サマーシンポジウム
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Detection of Multiple Blocked Locations in Parallelized Microreactors2016

    • Author(s)
      Satoshi Taniguchi, Kei Hata, Osamu Tonomura, and Shinji Hasebe
    • Organizer
      7th International Symposium on Design, Operation and Control of Chemical Processes (PSE Asia)
    • Place of Presentation
      東京大学(東京都・文京区)
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 並列マイクロ化学プロセスの設計と操作2016

    • Author(s)
      殿村修
    • Organizer
      化学工学会反応工学部会マイクロ化学プロセス分科会 第7回討論交流会
    • Place of Presentation
      三重マリンセンター海の学舎(三重県・津市)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] モノリス充填マイクロリアクタの並列化と運転監視2016

    • Author(s)
      西和希,多賀敏暉,殿村修,谷口智,永木愛一郎,廣瀬勝幸,吉田潤一,石塚紀生,長谷部伸治
    • Organizer
      化学工学会第81年会
    • Place of Presentation
      関西大学(大阪・吹田市)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Design of Flow Distributor with Orifices for Realizing Uniform Flow Distribution with Low Pressure Drop2015

    • Author(s)
      Osamu Tonomura, Takahiro Momono, Satoshi Taniguchi, and Shinji Hasebe
    • Organizer
      Flow Chemistry Congress 2015
    • Place of Presentation
      San Diego (US)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 外部並列マイクロリアクタの圧力変化による閉塞診断のための流体分配装置設計2015

    • Author(s)
      多賀敏暉,谷口智,殿村修,長谷部伸治
    • Organizer
      化学工学会第47回秋季大会
    • Place of Presentation
      北海道大学(北海道・札幌)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Design and Operation Procedures of Micro Chemical Devices and Plants for Mass Production2015

    • Author(s)
      Shinji Hasebe, Osamu Tonomura, Taisuke Maki, and Kazuhiro Mae
    • Organizer
      7th International Conference on Green and Sustainable Chemistry and 4th JACI/GSC Symposium
    • Place of Presentation
      Hitotsubashi University (Tokyo・Chiyoda)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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