Development of crystallization process using fast gas dissolution from a microbubble

• Project/Area Number: 15K18266
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Reaction engineering/Process system
• Research Institution: Keio University
• Principal Investigator: FUJIOKA Satoko 慶應義塾大学, 理工学部(矢上), 講師 (50571361)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: マイクロバブル / 微細気泡 / 溶解 / 収縮 / 溶解速度 / 界面活性剤 / マイクロ流路

Outline of Final Research Achievements

Dissolution rate of a microbubble is large due to Laplace pressure. A novel crystallization technique has been proposed using fast gas dissolution from a microbubble. It is necessary to know the dissolution rate of a single microbubble and concentration distribution around a bubble for a process design. In this study, we developed a prediction model of dissolution rate for a microbubble coated by surfactant in a stationary liquid.

Academic Significance and Societal Importance of the Research Achievements

マイクロバブル溶解を利用した晶析は、気泡周囲に形成される高溶存気体濃度領域を利用するため、希薄溶液からの結晶製造が可能、また結晶個数の制御が可能になると期待され、医薬品など高付加価値な製品の製造に有用であると考えられる。本研究では、種々の界面活性剤が吸着したマイクロバブルの溶解速度を予測可能にしたため、化学産業や医療分野における様々な物質の高効率な製造プロセス設計に利用できると期待される。

Research Products

• [Presentation] マイクロバブルの溶解収縮と材料合成への応用 (2019)
  • Author(s): 藤岡沙都子
  • Organizer: 化学工学会第84年会
  • Invited
• [Presentation] Applications of Microbubbles in The Manufacture of Chemical Products (2018)
  • Author(s): Satoko FUJIOKA
  • Organizer: 1st International Workshop on the Application of Fine and Ultrafine Bubbles
  • Int'l Joint Research
• [Presentation] マイクロバブルの溶解収縮と化学プロセスへの応用 (2018)
  • Author(s): 藤岡沙都子
  • Organizer: 第2回ソフト粒子・界面研究会
  • Invited
• [Presentation] Dissolution Behavior of a Single Mirobubble Accumulating Dissolved Gas Around Its Surface (2018)
  • Author(s): Kanako MIZUNO, Satoko FUJIOKA and Koichi TERASAKA
  • Organizer: 6th International Workshop on Process Intensification
  • Int'l Joint Research
• [Presentation] Mass Transfer during a gas dissolution process around a stationary single microbubble (2017)
  • Author(s): Tomoaki Shigehisa, Satoko Fujioka and Koichi Terasaka
  • Organizer: 13th International Conference on Gas-Liquid and Gas-Liquid-Solid Reactor Engineering
  • Int'l Joint Research
• [Presentation] Generation of high-concentration spot by rapid gas dissolution from a shrinking single bubble into water (2016)
  • Author(s): Tomoaki SHIGEHISA, Satoko FUJIOKA, Koichi TERASAKA
  • Organizer: International Workshop on Process Intensification
  • Place of Presentation: Manchester (UK)
  • Year and Date: 2016-09-29
• [Presentation] Dissolution and Shrinking Behavior of a Microbubble in a Microchannel (2015)
  • Author(s): Satoko FUJIOKA, Kaori IKEDA and Koichi TERASAKA
  • Organizer: APCChE2015
  • Place of Presentation: melbourne(Australia)
  • Year and Date: 2015-09-27
  • Int'l Joint Research