| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
It has been investigated about the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers. Span and Tween series surfactants were employed to prepare various kinds of self-assembled aggregates. Spherical micelle was prepared by Tween surfactants. Mixing with Span surfactants changed formation from a micelle to a vesicle. These aggregates were characterized by DSC, 1H NMR and Laurdan. Micelles were dynamic, while vesicles were rigid state. Therefore, hydrophobic molecules easily entered hydrophobic region of micelles as compared with vesicles. This result shows the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers, and it is important to understand systematically about the formation-dependent physicochemical properties of aggregates for “tailor-made drug carrier”.
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