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Calcium imaging of adult born neurons during learning tasks

Research Project

Project/Area Number 15K18332
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo

Principal Investigator

Sugaya Yuki  東京大学, 大学院医学系研究科(医学部), 助教 (00625759)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords海馬 / 神経細胞新生 / 歯状回 / 神経新生 / 記憶
Outline of Final Research Achievements

Neurogenesis persists throughout life in the dentate gyrus of mammals. Many previous studies reported the role of newborn neurons in memory consolidation, memory extinction, forgetting and pattern separation. However, the detailed activity of newly generated neurons during behavioral task was still unclear. In this study, we performed calcium imaging of the activity of newly-generated young neurons and compared them with that of old neurons. We found that the activity of young neurons was rather stable when compared to that of old neurons. Young neurons are considered to suppress the activity of old neurons and the increase of the activity of old neurons resulted in impaired retrieval of memory. These results suggest that the suppression of the activity of old neurons by newly-generated neurons reduces the noise and increases the accuracy of memory expression by old neurons.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] “Dentate granule cell activity during fear memory retrieval and extinction in freely moving mice2016

    • Author(s)
      Alvaro Carrier Ruiz, Yuki Sugaya and Masanobu Kano
    • Organizer
      第47回 生理研国際シンポジウム
    • Place of Presentation
      生理学研究所(愛知県・岡崎市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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