Analysis of the locus coeruleus noradrenaline neurological function
| Project/Area Number |
15K18336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 青斑核 / ノルアドレナリン神経 / ファイバーフォトメトリー / 光遺伝学 / 自律応答 / ノルアドレナリン / カルシウム計測 / In vivo カルシウム計測 / 青班核 / 疼痛 / 睡眠障害 |
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| Outline of Final Research Achievements |
In this study, I investigated two tpopics : 1)whether activity of noradrenergic neurons would change in association with animal behavior, and 2)whether manipulation of noradrenergic neuron activity induce animal behavior.
1)By using the fiber photometry system, I succeeded in recording the activity of noradrenergic neurons from the free-moving-mouse in real time. The neural activity immediately increased after acute nociceptive stimuli.
2)By using optogenetics systems and telemeter systems, I succeeded in recording body temperature and heart rate during manipulating the activity of noradrenergic neurons. My data suggested correlation between activity of noradrenergic neurons and heart rate.
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Report
(3 results)
Research Products
(10 results)
