| Project/Area Number |
15K18338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経科学 / 分子生物学 / ライブイメージング / シナプス可塑性 / 抑制性長期増強 / 抑制性長期抑圧 / GABA受容体 / 全反射顕微鏡 / 抑制性シナプス / Gephyrin / 細胞生物学 / 抑制性長期増強現象 / エキソサイトーシス / エンドサイトーシス |
|---|
| Outline of Final Research Achievements |
The efficacy of synaptic transmission changes depending on the pattern of neuronal activity. This synaptic plasticity has been regarded as a cellular basis of learning and memory. In this study, we have suggested that the amounts of gamma-aminobutyric acid receptor on postsynaptic membrane and gephyrin are changed during hippocampal inhibitory synaptic plasticity by experiments using total internal reflection fluorescence microscopy. In addition, we have succeeded in visualization of transient increase of glutamate receptors’ endocytosis during hippocampal long-term depression
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