Neural basis of timing control in motor sequence
| Project/Area Number |
15K18340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 時間制御 / synfire chain / 小鳥 / 温度操作 / 細胞内膜電位記録 / システム神経科学 / 細胞内記録 / songbird / temperature manipulation / brainstem feedback / sequential activity / intracellular recording |
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| Outline of Final Research Achievements |
Vocal control requires the interplay between the cortical and subcortical regions, however, their dynamical interaction during vocalization was remain elusive. Songbirds learn and sing highly complex vocal patterns and their cortical and subcortical song nuclei necessary for learning and singing were well identified. Therefore, they serve as a suitable model animal to study the interaction between cortical-subcortical regions during vocalization of learned sounds. Previous hypothesis postulated that cortical regions contain a chain like structure to generate precise timing to control the precise vocal gestures. However, we have shown that, by using peltier brain cooling, computer simulations, and intracellular recordings in singing birds, songs are the product of the cortical and subcortical chain structure instead of localized chain in the cortex.
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Report
(3 results)
Research Products
(6 results)
