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Neural basis of timing control in motor sequence

Research Project

Project/Area Number 15K18340
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionKyoto University

Principal Investigator

Hamaguchi Kosuke  京都大学, 医学研究科, 講師 (50415270)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords時間制御 / synfire chain / 小鳥 / 温度操作 / 細胞内膜電位記録 / システム神経科学 / 細胞内記録 / songbird / temperature manipulation / brainstem feedback / sequential activity / intracellular recording
Outline of Final Research Achievements

Vocal control requires the interplay between the cortical and subcortical regions, however, their dynamical interaction during vocalization was remain elusive. Songbirds learn and sing highly complex vocal patterns and their cortical and subcortical song nuclei necessary for learning and singing were well identified. Therefore, they serve as a suitable model animal to study the interaction between cortical-subcortical regions during vocalization of learned sounds. Previous hypothesis postulated that cortical regions contain a chain like structure to generate precise timing to control the precise vocal gestures. However, we have shown that, by using peltier brain cooling, computer simulations, and intracellular recordings in singing birds, songs are the product of the cortical and subcortical chain structure instead of localized chain in the cortex.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2016 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Int'l Joint Research] Duke University(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] A Distributed Recurrent Network Contributes to Temporally Precise Vocalizations2016

    • Author(s)
      K. Hamaguchi, M. Tanaka, R. Mooney
    • Journal Title

      Neuron

      Volume: 91(3) Issue: 3 Pages: 680-93

    • DOI

      10.1016/j.neuron.2016.06.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Distributed encoding of vocal timing revealed by brain cooling and intracellular recordings in singing birds2016

    • Author(s)
      Kosuke Hamaguchi
    • Organizer
      International Society for Neuroethology
    • Place of Presentation
      Montevideo, Uruguay
    • Year and Date
      2016-04-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distributed encoding of vocal timing revealed by brain cooling and intracellular recordings in singing birds2016

    • Author(s)
      Kosuke Hamaguchi
    • Organizer
      Satellite meeting of ICN2016
    • Place of Presentation
      Montevideo, Uruguay
    • Year and Date
      2016-04-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Distributed encoding of vocal timing revealed by brain cooling and intracellular recordings in singing birds2016

    • Author(s)
      Kosuke Hamaguchi, Masashi Tanaka, Richard Mooney
    • Organizer
      International Congress of Neuroethology 2016
    • Place of Presentation
      Montevideo, Uruguay
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distributed encoding of vocal timing revealed by brain cooling and intracellular recordings in singing birds2016

    • Author(s)
      Kosuke Hamaguchi
    • Organizer
      Satellite Meeting of ICN2016
    • Place of Presentation
      Montevideo, Uruguay
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2018-03-22  

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