| Project/Area Number |
15K18344
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
Nagase Masashi 東京慈恵会医科大学, 医学部, ポスト・ドクトラルフェロー (40749462)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 樹状突起内統合 / アストロサイト / ラクテート / 扁桃体 / エネルギー代謝 / パッチクランプ / カルシウムイメージング |
|---|
| Outline of Final Research Achievements |
I aimed to reveal the roles of astrocyte-neuron energetic interaction in maintaining excitatory synaptic inputs from distinct origins and the mechanisms of dendritic integration of these inputs. I focused on the central amygdala because the inputs from two distinct origins form excitatory synapses on the distinct dendritic compartments, spines and dendritic shafts. I found that energy supply through lactate transfer from astrocytes was indispensable to maintain excitatory synaptic transmissions at both spine and shaft excitatory synapses. I also found that calcium rises associated with these synaptic inputs were observed at distinct dendritic compartments and propagating into the overlapping compartments in a manner that depends on the location of calcium rise initiation and the frequency of the synaptic inputs.
|
