| Project/Area Number |
15K18353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Iwata Ryo 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 訪問研究員 (50612131)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 嗅細胞 / 嗅球 / 時間コーディング / シナプス前抑制 / ２光子イメージング / カルシウムイメージング |
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| Outline of Final Research Achievements |
Environmental olfactory signals are sensed by olfactory sensory neurons (OSNs) in the olfactory epithelia (OE), and are represented by both the firing rate and temporal patterns of neuronal activity in mitral/tufted (M/T) cells of the olfactory bulb (OB). The temporal patterns in M/T cells are shaped by input from the OE and modulations in the OB neuronal circuit. This study developed new techniques for in vivo calcium imaging in the OE, and revealed the difference of response patterns between somata (OE) and axon terminals (OB) of OSNs. To investigate neural processing mechanisms in the OSN axon terminals, this study also examined the functions of the presynaptic inhibition circuit in the OB.
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