| Project/Area Number |
15K18355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Tao Kentaro 国立研究開発法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (10708481)
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| Research Collaborator |
FUJISAWA Shigeyoshi 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー (20589395)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 電気生理学 / ドパミン |
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| Outline of Final Research Achievements |
To investigate how midbrain dopamine neurons encode action and reward on a fine time-scale, we established a probabilistic reversal learning paradigm in head-fixed mice using two levers. By recording activity of optogenetically-identified dopamine neurons from the substantia nigra pars compacta (SNc), we found that dopamine neurons were classified into several groups in terms of action and reward representation. A subset of dopamine neurons encoded both reward prediction error and trial value within a single trial.
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