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Laminar organization of the entorhinal cortex - Circuit that process sensory information to the hippocampus

Research Project

Project/Area Number 15K18358
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionTohoku University

Principal Investigator

Ohara Shinya  東北大学, 生命科学研究科, 助教 (10570038)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords嗅内皮質 / カルビンジン陽性ニューロン
Outline of Final Research Achievements

The entorhinal cortex, which is the major gateway between the hippocampus and the neocortex, plays an important role in the hippocampus-memory system. In this study we used several tracing techniques and examined the organization of the local circuits of layer IIb and Vb of the lateral entorhinal cortex, which have been overlooked in previous anatomical studies. We have shown that the neurons in these layers are in part of the neural circuits which are known to convey sensory information to the hippocampus. These anatomical data would be important to understand the mechanisms of the hippocampus-memory system in future studies.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 11 results)

  • [Int'l Joint Research] NTNU(Norway)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] NTNU(Norway)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Parahippocampal and retrosplenial connections of rat posterior parietal cortex.2017

    • Author(s)
      Olsen GM, Ohara S, Iijima T, Witter MP
    • Journal Title

      Hippocampus

      Volume: 27(4) Issue: 4 Pages: 335-358

    • DOI

      10.1002/hipo.22701

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of G-gene Deletion and Replacement on Rabies Virus Vector Gene Expression.2015

    • Author(s)
      Sho Sato, Shinya Ohara, Ken-Ichiro Tsutsui, Toshio Iijima
    • Journal Title

      PLoS One

      Volume: 10(5)

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Efferent projections of the calbindin-positive entorhinal neurons in the rat: Connectional differences between the medial and lateral entorhinal cortex.2016

    • Author(s)
      Ohara S., Itou K., Shiraishi M., Gianatti M., Sota Y., Kabashima S., Onodera M., Tsutsui K-I., Witter, M., Iijima T.
    • Organizer
      46th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Connectional differences between calbindin positive neurons in the medial and lateral entorhinal cortex of the rat.2016

    • Author(s)
      Ohara S., Itou K., Shiraishi M., Gianatti M., Sota Y., Kabashima S., Onodera M., Tsutsui K-I., Witter, M., Iijima T.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Connectional differences between layer Va and Vb neurons in the lateral entorhinal cortex of the rat.2016

    • Author(s)
      Onodera M., Ohara S., Shiraishi M., Itou K., Tsutsui K-I., Witter, M., Iijima T.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Decision related activities of anterior insular and orbitofrontal cortex in a gambling behavior of rats.2016

    • Author(s)
      Ishii H., Kaizu Y., Takahashi S., Ohara S., Tobler P., Tsutsui K-I., Iijima T.
    • Organizer
      46th Annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cortical and subcortical projections of the entorhinal layer III neurons of the rat2015

    • Author(s)
      Shinya Ohara, Kazuki Ito, Yasuhiro Sota, Ken-Ichiro Tsutsui, Meno P. Witter, Toshio Iijima
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rabies virus vector with improved transgene expression level for transsynaptic tracing2015

    • Author(s)
      Yasuhiro Sota, Shinya Ohara, Sho Sato, Kazuki Ito, Ken-Ichiro Tsutsui, Toshio Iijima
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of neural representations between rat anterior insular and orbitofrontal cortex in risky decision making2015

    • Author(s)
      Hironori Ishii, Yuta Kaizu, Shohei Takahashi, Shinya Ohara, Philippe N Tobler, Ken-Ichiro Tsutsui, Toshio Iijima
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural responses observed only in a gambling task in the rat anterior insular cortex2015

    • Author(s)
      Yuta Kaizu, Hironori Ishii, Shohei Takahashi, Shinya Ohara, Philippe N Tobler, Ken-Ichiro Tsutsui, Toshio Iijima
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cytoarchitectonic information of rat medial prefrontal “delay” neurons revealed by single-neuron electroporation2015

    • Author(s)
      Kei Oyama, Yukina Tateyama, Cheuk Wa Christopher Lo, Shinya Ohara,Fuyuki Karube,Fumino Fujiyama, Toshio Iijima, Ken-Ichiro Tsutsui
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 嗅内皮質Ⅲ層の交連性投射ニューロンの入出力解析2015

    • Author(s)
      大原 慎也、伊藤 和貴、曽田 泰宏、佐藤 翔、筒井 健一郎、飯島 敏夫
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 電気穿孔法による、遅延反応課題の遅延期間において持続的な活動を示すラット内側前頭連合野ニューロンの形態学的同定2015

    • Author(s)
      小山 佳、舘山 幸菜、Cheuk Wa Christopher Lo、大原 慎也、苅部 冬紀、藤山 文乃、飯島 敏夫、筒井 健一郎
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] リスクを伴う意思決定における島皮質前部の神経活動2015

    • Author(s)
      石井 宏憲、海津 祐太、高橋 勝平、大原 慎也、Tobler N Philippe、筒井 健一郎、飯島 敏夫
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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