Elucidation of the sleep-inducing neuronal system

• Project/Area Number: 15K18359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: University of Tsukuba
• Principal Investigator: OISHI Yo 筑波大学, 国際統合睡眠医科学研究機構, 助教 (70554004)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 睡眠 / モチベーション / ジフテリア毒素

Outline of Final Research Achievements

The mechanism of sleep-wake control by motivation is unclear. We discovered a sleep increasing effect through the ventral pallidum of the basal forebrain by selective activation of the adenosine A2A receptor expressing neurons of the nucleus accumbens in the basal ganglia. Motivational stimuli decreased the activity of the nucleus accumbens A2A receptor neurons that project to the ventral pallidum, and the sleep amount was decreased accordingly. These results indicate that the nucleus accumbens and ventral pallidum have important roles in motivation-related sleep regulation.

Research Products

• [Journal Article] Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice (2017)
  • Author(s): Oishi Yo、Xu Qi、Wang Lu、Zhang Bin-Jia、Takahashi Koji、Takata Yohko、Luo Yan-Jia、Cherasse Yoan、Schiffmann Serge N.、de Kerchove d’Exaerde Alban、Urade Yoshihiro、Qu Wei-Min、Huang Zhi-Li、Lazarus Michael
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 1-12
  • DOI: 10.1038/s41467-017-00781-4
  • NAID: 120007134733
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The control of sleep and wakefulness by mesolimbic dopamine systems (2017)
  • Author(s): Oishi Yo、Lazarus Michael
  • Journal Title: Neuroscience Research Volume: 118 Pages: 66-73
  • DOI: 10.1016/j.neures.2017.04.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D2-like receptors in mice (2017)
  • Author(s): Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M
  • Journal Title: Brain Structure & Function Volume: - Issue: 6 Pages: 1-9
  • DOI: 10.1007/s00429-017-1365-7
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] The role of ventral midbrain neurons in sleep-wake regulation (2018)
  • Author(s): Yo Oishi, Yohko Takata, Michael Lazarus
  • Organizer: Gordon Research Conference on Sleep Regulation and Function meeting
  • Int'l Joint Research
• [Presentation] The role of nucleus accumbens on sleep regulation (2017)
  • Author(s): Yo Oishi
  • Organizer: World Sleep 2017
  • Int'l Joint Research
• [Remarks] Why do we fall asleep when bored?
  • URL: https://wpi-iiis.tsukuba.ac.jp/news/705/