Functional anatomy of the medial preoptic area

• Project/Area Number: 15K18364
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Toho University
• Principal Investigator: TSUNEOKA Yousuke 東邦大学, 医学部, 講師 (50549011)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: MPOA / 養育行動 / 性行動 / 攻撃行動 / 性ホルモン受容体 / c-Fos / 内側視索前野

Outline of Final Research Achievements

The medial preoptic area (MPOA) is located at the anterior portion of the hypothalamus. This area has been known to be the brain center for the widely diverse behaviors. However, little is known for their function and anatomy because of the heterogeneity and complexity of the MPOA anatomy. We reviewed the anatomy of the MPOA subregions by using molecular markers, and developed the atlas of the MPOA. We also reported the gonadal steroid hormone receptor expressions in the MPOA with the molecular marker expression. Based on these results, we assessed the neural activity during various instinctive behaviors by means of histological analyses of c-Fos expression. In addition, using cre-loxp mediated manipulation of the neural activity, the responsible cell groups for regulating various behavior were determined.

Research Products

• [Journal Article] Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex (2018)
  • Author(s): Oda Satoko、Tsuneoka Yousuke、Yoshida Sachine、Adachi-Akahane Satomi、Ito Masanori、Kuroda Masaru、Funato Hiromasa
  • Journal Title: Journal of Comparative Neurology Volume: 526 Issue: 8 Pages: 1329-1350
  • DOI: 10.1002/cne.24409
  • Peer Reviewed / Open Access
• [Journal Article] Neurotransmitters and neuropeptides in gonadal steroid receptor-expressing cells in medial preoptic area subregions of the male mouse (2017)
  • Author(s): Yousuke Tsuneoka, Sachine Yoshida, Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 1-16
  • DOI: 10.1038/s41598-017-10213-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Moxd1 Is a Marker for Sexual Dimorphism in the Medial Preoptic Area, Bed Nucleus of the Stria Terminalis and Medial Amygdala (2017)
  • Author(s): Tsuneoka Y and Funato H et al.
  • Journal Title: Front Neuroanat Volume: 11 Pages: 26-26
  • DOI: 10.3389/fnana.2017.00026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice (2017)
  • Author(s): Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
  • Journal Title: Psychoneuroendocrinology Volume: 79 Pages: 20-30
  • DOI: 10.1016/j.psyneuen.2017.01.036
  • Peer Reviewed / Open Access
• [Journal Article] マウス内側視索前野の養育行動における役割 (2015)
  • Author(s): 恒岡洋右
  • Journal Title: 東邦医学会雑誌 Volume: 62 Pages: 117-119
• [Presentation] マウス内側視索前野における神経ペプチドｍRNA発現と性的二型 (2018)
  • Author(s): 恒岡洋右, 吉田さちね, 小田哲子, 黒田優, 船戸弘正
  • Organizer: 第123回日本解剖学会大会
• [Presentation] 性的二型核マーカーMoxd1の内側視索前野における発現. (2017)
  • Author(s): 恒岡洋右, 塚原伸治, 吉田さちね, 小田哲子, 黒田優, 船戸弘正
  • Organizer: 第122回日本解剖学会
  • Place of Presentation: 長崎県長崎市 長崎大学
  • Year and Date: 2017-03-27
• [Presentation] マウス内側視索前野の性ホルモン受容体発現細胞における分子組成 (2016)
  • Author(s): 恒岡洋右、吉田さちね、小田哲子、船戸弘正、黒田優
  • Organizer: 第25回日本行動神経内分泌研究会
  • Place of Presentation: 静岡県熱海市 ホテル・サンミ倶楽部
  • Year and Date: 2016-09-15
• [Presentation] 生得的社会行動を制御する内側視索前野の機能解剖学的解析 (2016)
  • Author(s): 恒岡洋右、吉田さちね、小田哲子、黒田 優、船戸弘正
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま（福島県郡山市）
  • Year and Date: 2016-03-28
  • Invited
• [Presentation] Functional neuroanatomy of the medial preoptic area: a study on its functional and anatomical heterogeneity (2015)
  • Author(s): Tsuneoka Y, Yoshida S,Oda S, Kuroda M, Funato H
  • Organizer: The 38th annual meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-07-29