Functional anatomy of the medial preoptic area
| Project/Area Number |
15K18364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MPOA / 養育行動 / 性行動 / 攻撃行動 / 性ホルモン受容体 / c-Fos / 内側視索前野 |
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| Outline of Final Research Achievements |
The medial preoptic area (MPOA) is located at the anterior portion of the hypothalamus. This area has been known to be the brain center for the widely diverse behaviors. However, little is known for their function and anatomy because of the heterogeneity and complexity of the MPOA anatomy. We reviewed the anatomy of the MPOA subregions by using molecular markers, and developed the atlas of the MPOA. We also reported the gonadal steroid hormone receptor expressions in the MPOA with the molecular marker expression. Based on these results, we assessed the neural activity during various instinctive behaviors by means of histological analyses of c-Fos expression. In addition, using cre-loxp mediated manipulation of the neural activity, the responsible cell groups for regulating various behavior were determined.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017
Author(s)
Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
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Journal Title
Psychoneuroendocrinology
Volume: 79
Pages: 20-30
DOI
Related Report
Peer Reviewed / Open Access
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