The role of Ndrg2 in multiple sclerosis

• Project/Area Number: 15K18374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kanazawa University
• Principal Investigator: Takarada Mika 金沢大学, 医学系, 助教 (40565412)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アストロサイト / 多発性硬化症 / 脱髄 / 炎症 / Ndrg2

Outline of Final Research Achievements

Multiple sclerosis (MS) is autoimmune disease of the central nervous system (CNS), however, the involvement of the CNS parenchymal cells to the pathology is not fully elucidated. N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation-associated molecule predominantly expressed in astrocytes in the central nervous system. In this study, we examined the expression and the role of Ndrg2 in MS pathology, and its underlying mechanisms using a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). The current study demonstrated that Ndrg2 is involved in neurological symptom through the regulation of motor neuron damages during the pathogenesis of EAE.

Research Products

• [Journal Article] CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously. (2017)
  • Author(s): Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Ta HM, Le TM, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.
  • Journal Title: Glia Volume: 印刷中 Issue: 6 Pages: 974-989
  • DOI: 10.1002/glia.23139
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis. (2016)
  • Author(s): Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O.
  • Journal Title: Journal of Neurochemistry Volume: 139 Issue: 6 Pages: 1124-1137
  • DOI: 10.1111/jnc.13714
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson's Disease (2016)
  • Author(s): Le TM, Hashida K, Ta HM, Takarada-Iemata M, Kokame K, Kitao Y, Hori O
  • Journal Title: Parkinsons Dis. Volume: 1 Pages: 1-9
  • DOI: 10.1155/2016/6163934
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Deletion of Atf6α enhances kainate-induced neuronal death in mice (2016)
  • Author(s): Kezuka D, Tkarada-Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, Hori O
  • Journal Title: Neurochem Int. Volume: 92 Pages: 67-74
  • DOI: 10.1016/j.neuint.2015.12.009
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 網膜神経細胞死に起因するシグナル連関における小胞体ストレス応答の重要性 (2017)
  • Author(s): 宝田 美佳、沖谷なほ子、郡山 恵樹、北尾 康子、堀 修
  • Organizer: 第1回Neuro-vascular Meeting
  • Place of Presentation: 神戸薬科大学、神戸
• [Presentation] 中枢神経系疾患におけるアストロサイト (2016)
  • Author(s): 宝田 美佳
  • Organizer: 第59回日本神経化学会大会第9回神経化学の若手研究者育成セミナー
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2016-09-08
• [Presentation] Atf6alpha deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis (2016)
  • Author(s): Ta Minh Hieu、Le Manh Thuong、石井宏史、宝田美佳、服部剛志、森 和俊、高橋 良輔、北尾康子、堀 修
  • Organizer: 第59回日本神経化学会大会
  • Place of Presentation: 福岡国際会議場、福岡
  • Year and Date: 2016-09-08
• [Presentation] 軸索傷害性神経細胞死における小胞体ストレス応答の保護的効果 (2016)
  • Author(s): 宝田 美佳、郡山 恵樹、北尾 康子、堀 修
  • Organizer: 第17回ORIGIN神経科学研究会
  • Place of Presentation: 芦原温泉まつや千千、福井
  • Year and Date: 2016-08-27
• [Presentation] Involvement of Ndrg2 in blood-brain barrier disruption after stroke (2015)
  • Author(s): 宝田美佳、吉川陽文、会田泰裕、Ta Minh Hieu、服部剛志、Le Thuong Manh、北尾康子、中田光俊、堀修
  • Organizer: 第58回 日本神経化学会大会
  • Place of Presentation: さいたま市大宮ソニックシティ
  • Year and Date: 2015-09-11
• [Remarks] http://med03.w3.kanazawa-u.ac.jp/
• [Remarks] 金沢大学 神経分子標的学
  • URL: http://med03.w3.kanazawa-u.ac.jp/