A novel role of alpha2-antiplasmin in memory formation and age-related cognitive decline

• Project/Area Number: 15K18380
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: KAWASHITA ERI 京都薬科大学, 薬学部, 助教 (80509266)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: α2-antiplasmin / 記憶 / 老化 / α2-antplasmin / 加齢 / アンチプラスミン / 線維素溶解系因子

Outline of Final Research Achievements

The goal of this study is to elucidate the roles of α2-antiplasmin in memory formation and age-related cognitive decline. We demonstrated that α2-antiplasmin is involved in memory formation and retention. We also found that the increased level of α2-antiplasmin might lead to age-related cognitive decline.

Research Products

• [Journal Article] CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive Decline (2016)
  • Author(s): Kuriyama N, Mizuno T, Yasuike H, Matsuno H, Kawashita E, Tamura A, Ozaki E, Matsui D, Watanabe I, Koyama T, Miyatani F, Kondo M, Tokuda T, Ohshima Y, Muranishi M, Akazawa K, Takada A, Takeda K, Matsumoto S, Mizuno S, Yamada K, Nakagawa M, Watanabe Y.
  • Journal Title: Arch. Gerontol. Geriatr. Volume: 62 Pages: 118-124
  • DOI: 10.1016/j.archger.2015.09.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] uPA attenuated LPS-induced inflammatory osteoclastogenesis through the plasmin/PAR-1/Ca2+/CaMKK/AMPK axis. (2016)
  • Author(s): Kanno Y, Ishisaki A, Kawashita E, Kuretake H, Ikeda K, Matsuo O.
  • Journal Title: Int J Biol Sci. Volume: 12 Issue: 1 Pages: 63-71
  • DOI: 10.7150/ijbs.12690
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Enhancement by Uridine Diphosphate of Macrophage Inflammatory Protein-1 Alpha Production in Microglia Derived from Sandhoff Disease Model Mice (2015)
  • Author(s): Eri Kawashita, Daisuke Tsuji, Yosuke Kanno, Kaho Tsuchida, Kohji Itoh
  • Journal Title: J of Inherited metabolic Disease Reports Volume: Nov Pages: 1-9
  • DOI: 10.1007/8904_2015_496
  • ISBN: 9783662528464, 9783662528471
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Alpha2-antiplasmin as a potential mediator contributing to memory function and age-related cognitive decline. (2016)
  • Author(s): Eri Kawashita, Keiichi Ishihara, Osamu Matsuo, Satoshi Akiba
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
• [Presentation] α2-Antiplasmin as a potential mediator contributing to memory function and age-related cognitive decline (2016)
  • Author(s): Eri Kawashita, Keiichi Ishihara, Osamu Matsuo, Satoshi Akiba
  • Organizer: Society for Neuroscience's 46th annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 線維素溶解系因子の中枢神経機能における生理的・病理的役割の解明 (2015)
  • Author(s): 河下映里、秋葉聡、石原慶一、松尾理
  • Organizer: 第5回4大学連携研究フォーラム
  • Place of Presentation: 京都工芸繊維大学
  • Year and Date: 2015-11-25