A novel role of alpha2-antiplasmin in memory formation and age-related cognitive decline
Project/Area Number |
15K18380
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
KAWASHITA ERI 京都薬科大学, 薬学部, 助教 (80509266)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | α2-antiplasmin / 記憶 / 老化 / α2-antplasmin / 加齢 / アンチプラスミン / 線維素溶解系因子 |
Outline of Final Research Achievements |
The goal of this study is to elucidate the roles of α2-antiplasmin in memory formation and age-related cognitive decline. We demonstrated that α2-antiplasmin is involved in memory formation and retention. We also found that the increased level of α2-antiplasmin might lead to age-related cognitive decline.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive Decline2016
Author(s)
Kuriyama N, Mizuno T, Yasuike H, Matsuno H, Kawashita E, Tamura A, Ozaki E, Matsui D, Watanabe I, Koyama T, Miyatani F, Kondo M, Tokuda T, Ohshima Y, Muranishi M, Akazawa K, Takada A, Takeda K, Matsumoto S, Mizuno S, Yamada K, Nakagawa M, Watanabe Y.
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Journal Title
Arch. Gerontol. Geriatr.
Volume: 62
Pages: 118-124
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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