| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Central chondrosarcomas are known to harbor frequent mutation in IDH1 or IDH2 genes. The objective of the current study is to generate genetically-engineered mice expressing mutant IDH1 or IDH2 specifically in cartilage and to elucidate the underlying mechanism of chondrosarcoma occurrence and development. The mutant IDH1 or IDH2 mice exhibited dwarfism as compared to their wild-type littermate, with morphologically abnormal growth plate cartilage. Of note, the IDH2 mutant mice harbored severer phenotype in cartilage than the IDH1 mutant mice. The mutant IDH1 or IDH2 mice with p53 deficiency were generated by crossing with p53-flox mice. No clear evidence of bone tumor development has been observed until the age of three months old.
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