| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
(1) It was suggested that deregulated tyrosine-dephosphorylation of Parafibromin caused lethal defects in embryogenesis of mice. We reported that tyrosine-dephosphorylated form of Parafibromin acts as a coactivator of the Wnt/Hedgehog/Notch signaling pathways, which play crucial roles in morphogenesis.
(2) Loss of function of the leucine-zipper motif lost the SHP2-binding ability of the YAP isoform that possesses the exon 6-encoded γ-segment. The YAP isoform lacking the γ-segment was incapable in binding to SHP2, collectively indicated that YAP requires the leucine-zipper motif, which is encoded in the exon 5 and 7, for the complex formation with SHP2.
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