| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Inactivation of the tumor suppressor gene RB is frequently observed in cancer progression. We analyzed the model lacking RB additionally and found that thyroid C cells of RB ・ p53-deficient mice acquire high undifferentiated property. In addition, we also found that cancer stem cell-like populations appear due to the additional deficiency of RB in p53 deficient cancer cells. In this study, we focused on the metabolism of cancer stem cell - like population and analyzed its dynamics, revealing that PGAM is necessary for maintaining the undifferentiated state of cancer stem cell - like population. Furthermore, it was revealed that regulation of PGAM expression by RB is mediated through histone demethylase.
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