Analysis of reprogrammed metabolism by PGAM in cancer stem cell model
Project/Area Number |
15K18404
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Kanazawa University |
Principal Investigator |
Kohno Susumu 金沢大学, がん進展制御研究所, 助教 (30625463)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | PGAM / 糖代謝 / RB / がん幹細胞 / グルコース代謝 |
Outline of Final Research Achievements |
Inactivation of the tumor suppressor gene RB is frequently observed in cancer progression. We analyzed the model lacking RB additionally and found that thyroid C cells of RB ・ p53-deficient mice acquire high undifferentiated property. In addition, we also found that cancer stem cell-like populations appear due to the additional deficiency of RB in p53 deficient cancer cells. In this study, we focused on the metabolism of cancer stem cell - like population and analyzed its dynamics, revealing that PGAM is necessary for maintaining the undifferentiated state of cancer stem cell - like population. Furthermore, it was revealed that regulation of PGAM expression by RB is mediated through histone demethylase.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Undifferentiated State Induced by Rb-P53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts2015
Author(s)
Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, Mohammed MS, Muranaka H, Nagatani N, Suzuki M, Kido Y, Takahashi C
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Journal Title
STEM CELLS
Volume: -
Issue: 5
Pages: 1657-1669
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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