| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
Breast cancer is classified into five subtypes by gene expression profile. In case of breast cancers, cancer heterogeneity that some different subtypes cooperate to enhance malignant progression is proposed. It is suggested that cancer heterogeneity makes it difficult to develop cancer therapy. We elucidated that NFYA plays two different roles by switching the expression of splicing variants, thereby NFYA induces the switching of breast cancer subtypes and enhances the acquisition of cancer heterogeneity.
|
