Novel histone chaperone GRWD1 inhibits p53 and promotes tumorigenesis
| Project/Area Number |
15K18412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | GRWD1 / p53 / 発がん / MDM2 / RPL11 / p53反応性プロモーター / がん / Purα |
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| Outline of Final Research Achievements |
GRWD1 is a novel histone chaperone that promotes MCM loading and may integrate regulations of cell cycle progression. We identified ribosomal protein RPL11 as a putative GRWD1 binding factor. Under nucleolar stress induced by treatment with low levels of actinomycin D or nutrient deprivation, RPL11 binds to and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. We found that GRWD1 inhibits RPL11-MDM2 interaction, abrogates RPL11-mediated p53 stabilization, and promotes tumorigenesis.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.2017
Author(s)
Kayama K, Watanabe S, Takafuji T, Tsuji T, Hironaka K, Matsumoto M, Nakayama KI, Enari M, Kohno T, Shiraishi K, Kiyono T, Yoshida K, Sugimoto N, Fujita M.
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Journal Title
EMBO Rep.
Volume: 18
Issue: 1
Pages: 123-137
DOI
Related Report
Peer Reviewed
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