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Diagnostic and prognostic analysis for soft tissue tumor using inflammatory cytokine and micro RNA

Research Project

Project/Area Number 15K18429
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionMie University

Principal Investigator

NAKAMURA TOMOKI  三重大学, 医学部附属病院, 助教 (50467362)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsサイトカイン / インターロイキン / マイクロRNA / 軟部肉腫 / inflammation / Interleukin / Soft tissue tumor / Sarcoma / MicroRNA
Outline of Final Research Achievements

We measured several kind of cytokines. Interleukin(IL)-6 was related to diagnosis in 99 patients with soft tissue mass. But, other cytokines including IL-17 were not elevated using ELISA technique. C-reactive protein (CRP) was strong co-relation with IL-6. IL-6 was useful in differentiation between benign and malignant tumors. Furthermore, we analyzed prognostic variables including IL-6 in 59 patients with soft-tissue sarcoma. IL-6 was prognostic factor for survival and event-free survival in multivariate analysis. We conclude that IL-6 may be a useful marker for diagnosis of soft tissue mass and prognostic factors for survival in soft-tissue sarcoma. Now, we analyze the relationship between micro RNA and soft tissue sarcoma.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 軟部肉腫における治療前Interleukin-6濃度の意義2016

    • Author(s)
      中村 知樹
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場、福岡県福岡市
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of pre-treatment serum albumin and C-reactive protein levels in patients with soft tissue sarcoma2016

    • Author(s)
      Tomoki Nakamura
    • Organizer
      11th Asian Pacific Musculoskeletal Tumor Society Meeting
    • Place of Presentation
      Singapore (Singapore)
    • Year and Date
      2016-04-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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