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Identification of histon modifications to predict colorectal cancer risk

Research Project

Project/Area Number 15K18431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionSapporo Medical University

Principal Investigator

Harada Taku  札幌医科大学, 医学部, 研究員 (60468030)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords大腸がん / エピジェネティクス / DNAメチル化 / ヒストン修飾 / 大腸鋸歯状病変 / メチル化
Outline of Final Research Achievements

We found that genes marked by bivalent chromatin domain in ESCs are significantly associated with H3K27me3 in noncancerous colonic mucosa of patients with CIMP-positive tumors. Moreover, a large number of genes marked by H3K27me3 in noncancerous colonic mucosa were specifically methylated in CIMP-positive CRCs. In contrast, such enrichment of H3K27me3 was not observed in colonic mucosa of patients with CIMP-negative tumors. We identified a series of genes, which were marked by H3K27me3 in the background colonic mucosa of CIMP-positive CRCs and were aberrantly methylated in CIMP-positive CRCs. Our results suggest that H3K27me3 may act as a pre-mark in the noncancerous colon mucosa of patients at a high risk of CIMP-positive cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (2 results)

  • [Journal Article] Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer.2017

    • Author(s)
      Kai M, Yamamoto E, Sato A, Yamano HO, Niinuma T, Kitajima H, Harada T, Aoki H, Maruyama R, Toyota M, Hatahira T, Nakase H, Sugai T, Yamashita T, Toyota M, Suzuki H.
    • Journal Title

      Mol Carcinog

      Volume: - Issue: 7 Pages: 1743-1752

    • DOI

      10.1002/mc.22631

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.2016

    • Author(s)
      Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 12 Pages: e0168281-e0168281

    • DOI

      10.1371/journal.pone.0168281

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.2016

    • Author(s)
      Sawada T, Yamamoto E, Yamano HO, Nojima M, Harada T, Maruyama R, Ashida M, Aoki H, Matsushita HO, Yoshikawa K, Harada E, Tanaka Y, Wakita S, Niinuma T, Kai M, Eizuka M, Sugai T, Suzuki H.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 23 Pages: 35106-35118

    • DOI

      10.18632/oncotarget.9044

    • NAID

      120006534714

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors2015

    • Author(s)
      Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 30 Pages: 29975-90

    • DOI

      10.18632/oncotarget.5034

    • NAID

      130005161526

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 腸管洗浄液のメチル化解析による大腸癌診断法の検討2015

    • Author(s)
      原田 拓,鈴木 拓,山野 泰穂
    • Organizer
      JDDW 2015
    • Place of Presentation
      グランドプリンスホテル新高輪(東京、品川)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] BRAF変異を有する進行大腸癌の内視鏡的特徴2015

    • Author(s)
      檜森亮吾, 山野泰穂, 松下弘雄, 吉川健二郎, 原田英嗣, 高木亮, 田中義人, 中岡宙子, 吉田優子, 青木敬則, 山本英一郎, 鈴木拓, 菅井有
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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