| Project/Area Number |
15K18431
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Harada Taku 札幌医科大学, 医学部, 研究員 (60468030)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 大腸がん / エピジェネティクス / DNAメチル化 / ヒストン修飾 / 大腸鋸歯状病変 / メチル化 |
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| Outline of Final Research Achievements |
We found that genes marked by bivalent chromatin domain in ESCs are significantly associated with H3K27me3 in noncancerous colonic mucosa of patients with CIMP-positive tumors. Moreover, a large number of genes marked by H3K27me3 in noncancerous colonic mucosa were specifically methylated in CIMP-positive CRCs. In contrast, such enrichment of H3K27me3 was not observed in colonic mucosa of patients with CIMP-negative tumors. We identified a series of genes, which were marked by H3K27me3 in the background colonic mucosa of CIMP-positive CRCs and were aberrantly methylated in CIMP-positive CRCs. Our results suggest that H3K27me3 may act as a pre-mark in the noncancerous colon mucosa of patients at a high risk of CIMP-positive cancer.
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