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Novel therapeutic strategy for refractory osteosarcoma

Research Project

Project/Area Number 15K18451
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionJuntendo University

Principal Investigator

KUBOTA DAISUKE  順天堂大学, 医学部, 非常勤助教 (70638197)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨肉腫 / 治療抵抗性 / 酸化ストレス / miRNA / チロシンキナーゼ / 薬剤抵抗性 / 抗酸化 / 低酸素環境 / 抗がん剤抵抗性 / リン酸化 / 小分子化合物 / 腫瘍低酸素環境
Outline of Final Research Achievements

Osteosarcoma is the most common primary malignancy in bone. Patients who respond poorly to induction chemotherapy are at higher risk of adverse prognosis. The molecular basis for such poor prognosis remains unclear. In this study, we tried to identify novel therapeutic targets for chemo-resistant osteosarcomas. Previously, We investigated protein and miRNA expressions using biopsy samples to identify predictive of response to induction chemotherapy, and identified PRDX2 and miRNA biomarkers. These results suggested that they are also potential novel therapeutic target for osteosarcomas. In this study, we found that the treatments of OS cells with conoidin-A, which inhibits the function of peroxiredoxin, markedly suppressed their proliferation. Our findings indicate the possible application of PRDX2 as a predictive biomarker and a novel therapeutic target in patients with osteosarcoma.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016

All Presentation (4 results)

  • [Presentation] 腫瘍低酸素環境を標的とした骨肉腫の新規治療法開発2016

    • Author(s)
      窪田大介, 田邊 雄, 向井原健太, 末原義之, 小林英介, 金子和夫
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 網羅的発現解析に基づく骨軟部腫瘍のバイオマーカーの開発と新規治療法への応用2016

    • Author(s)
      窪田大介
    • Organizer
      第49回日本整形外科学会骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 腫瘍低酸素環境を標的とした骨肉腫の新規治療法開発2016

    • Author(s)
      窪田大介, 田邊 雄, 向井原健太, 末原義之, 小林英介, 金子和夫
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 腫瘍低酸素環境を標的とした骨肉腫の新規治療法の開発2016

    • Author(s)
      窪田大介
    • Organizer
      日本整形外科学会 学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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