| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we identified the human salivary bacterial species which have the ability to colonize gut, and evaluated their roles against the host cell immunology. To this aim, the gnotobiotic mice which were transplanted the human salivary microbiota from healthy adults and IBD patients were made. The result of flow cytometry of TH1 and Th17 cell indicated that the frequency of TH1 and TH17 cells increased in the several gnotobiotic mice compared with GF mice. We isolated several bacterial strains relating to the gut inflammation from these gnotobiotic feces.
|
