The effect of colonization of human saliva bacteria in the gut
Project/Area Number |
15K18461
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical genome science
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Research Institution | Keio University |
Principal Investigator |
Wataru Suda 慶應義塾大学, 医学部(信濃町), 講師 (20590847)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | ヒト常在細菌 / 唾液細菌叢 / ヒト常在細菌叢 / ノトバイオート / 炎症 / 炎症性腸疾患 |
Outline of Final Research Achievements |
In this study, we identified the human salivary bacterial species which have the ability to colonize gut, and evaluated their roles against the host cell immunology. To this aim, the gnotobiotic mice which were transplanted the human salivary microbiota from healthy adults and IBD patients were made. The result of flow cytometry of TH1 and Th17 cell indicated that the frequency of TH1 and TH17 cells increased in the several gnotobiotic mice compared with GF mice. We isolated several bacterial strains relating to the gut inflammation from these gnotobiotic feces.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Circadian oscillations of microbial and functional composition in the human salivary microbiome2017
Author(s)
Takayasu L, Suda W, Takanashi K, Iioka E, Kurokawa R, Shindo C, Hattori Y, Yamashita N, Nishijima S, Oshima K, Hattori M
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Journal Title
DNA Res.
Volume: 印刷中
Issue: 3
Pages: 261-270
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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