Structural study of regulation of ryanodine receptor

Research Project

Project/Area Number	15K18484
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Structural biochemistry
Research Institution	Tohoku University
Principal Investigator	Watanabe Satoshi 東北大学, 多元物質科学研究所, 助教 (50432357)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	構造解析 / カルシウム
Outline of Final Research Achievements	Structural studies of huge calcium channel, Ryanodine receptors (RyR) and its regulatory proteins Calsequestrin (CSQ) and Junctin (JCT) were performed. CSQ has been found to assume an extended conformation or a compact conformation, depending on the calcium concentration. CSQ and JCT formed heterogeneous complexes likely through electrostatic interactions.