| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Cytochrome c oxidase (CcO), which generates bioenergy by catalyzing O2 for maintain biological activity, is one of the most important protein in bioenergetics field. Understanding the reaction mechanism of CcO is not academically significant subject but also expected to be useful for caring hypoxic diseases. In this study, I succeeded in determining the damage-free CcO crystal structure using X-ray free electron laser which has billion times higher pulse-intensity and one thousandth shorter pulse-width than present X-ray. Furthermore, intermediate structures of CcO photoactivated by laser irradiation were determined by utilizing the extremely short pulse-width of XFEL.
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